Glycopeptide antibiotic analogs for selective inactivation and two-photon imaging of vancomycin-resistant strains

Shinya Ariyasu; Pei Chui Too; Jing Mu; Chi Ching Goh; Yichen Ding; Ya Lin Tnay; Edwin Kok Lee Yeow; Liang Yang; Lai Guan Ng; Shunsuke Chiba; Bengang Xing

doi:10.1039/c5cc10230h

Glycopeptide antibiotic analogs for selective inactivation and two-photon imaging of vancomycin-resistant strains

Shinya Ariyasu, Pei Chui Too, Jing Mu, Chi Ching Goh, Yichen Ding, Ya Lin Tnay, Edwin Kok Lee Yeow, Liang Yang, Lai Guan Ng, Shunsuke Chiba^*, Bengang Xing

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

A novel theranostic divalent vancomycin analog using a planar 1,8-diazapyrene moiety as a rigid scaffold exhibits potent and selective antibacterial activity against Gram (+) bacteria including vancomycin-resistant strains, while having minimal influence on Gram (-) bacteria and mammalian cells. Moreover, this theranostic analog can be also applied for selective two-photon fluorescence imaging of Gram (+) bacteria.

Original language	English
Pages (from-to)	4667-4670
Number of pages	4
Journal	Chemical Communications
Volume	52
Issue number	25
DOIs	https://doi.org/10.1039/c5cc10230h
Publication status	Published - Mar 28 2016
Externally published	Yes

Bibliographical note

Publisher Copyright:
© The Royal Society of Chemistry 2016.

ASJC Scopus Subject Areas

Electronic, Optical and Magnetic Materials
Catalysis
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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10.1039/c5cc10230h

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abstract = "A novel theranostic divalent vancomycin analog using a planar 1,8-diazapyrene moiety as a rigid scaffold exhibits potent and selective antibacterial activity against Gram (+) bacteria including vancomycin-resistant strains, while having minimal influence on Gram (-) bacteria and mammalian cells. Moreover, this theranostic analog can be also applied for selective two-photon fluorescence imaging of Gram (+) bacteria.",

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doi = "10.1039/c5cc10230h",

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AU - Ariyasu, Shinya

AU - Too, Pei Chui

AU - Mu, Jing

AU - Goh, Chi Ching

AU - Ding, Yichen

AU - Tnay, Ya Lin

AU - Yeow, Edwin Kok Lee

AU - Yang, Liang

AU - Ng, Lai Guan

AU - Chiba, Shunsuke

AU - Xing, Bengang

PY - 2016/3/28

Y1 - 2016/3/28

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AB - A novel theranostic divalent vancomycin analog using a planar 1,8-diazapyrene moiety as a rigid scaffold exhibits potent and selective antibacterial activity against Gram (+) bacteria including vancomycin-resistant strains, while having minimal influence on Gram (-) bacteria and mammalian cells. Moreover, this theranostic analog can be also applied for selective two-photon fluorescence imaging of Gram (+) bacteria.

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JO - Chemical Communications

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Glycopeptide antibiotic analogs for selective inactivation and two-photon imaging of vancomycin-resistant strains

Abstract

Bibliographical note

ASJC Scopus Subject Areas

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