Graphene quantum dots based fluorescence turn-on nanoprobe for highly sensitive and selective imaging of hydrogen sulfide in living cells

Nan Li; Aung Than; Jie Chen; Fengna Xi; Jiyang Liu; Peng Chen

doi:10.1039/c7bm00818j

Graphene quantum dots based fluorescence turn-on nanoprobe for highly sensitive and selective imaging of hydrogen sulfide in living cells

Nan Li, Aung Than, Jie Chen, Fengna Xi, Jiyang Liu, Peng Chen

Research output: Contribution to journal › Article › peer-review

48 Citations (Scopus)

Abstract

Hydrogen sulfide (H₂S), being an important gaseous signaling molecule, has been gaining increasing attention for its involvement in a wide range of physiological processes. Herein, we developed a novel fluorescence turn-on nanoprobe for selective and sensitive detection of H₂S based on graphene quantum dots (GQDs) conjugated with (2,4-dinitrophenoxy)tyrosine (DNPTYR). Taking advantage of its high fluorescence quantum yield, biocompatibility, photostability, and ease to be uptaken by cells, the GQD-based fluorescence probe was further employed for real-Time monitoring of the triggered dynamic change of the intracellular H₂S level in live cells.

Original language	English
Pages (from-to)	779-784
Number of pages	6
Journal	Biomaterials Science
Volume	6
Issue number	4
DOIs	https://doi.org/10.1039/c7bm00818j
Publication status	Published - Apr 2018
Externally published	Yes

Bibliographical note

Publisher Copyright:
© The Royal Society of Chemistry.

ASJC Scopus Subject Areas

Biomedical Engineering
General Materials Science

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10.1039/c7bm00818j

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abstract = "Hydrogen sulfide (H2S), being an important gaseous signaling molecule, has been gaining increasing attention for its involvement in a wide range of physiological processes. Herein, we developed a novel fluorescence turn-on nanoprobe for selective and sensitive detection of H2S based on graphene quantum dots (GQDs) conjugated with (2,4-dinitrophenoxy)tyrosine (DNPTYR). Taking advantage of its high fluorescence quantum yield, biocompatibility, photostability, and ease to be uptaken by cells, the GQD-based fluorescence probe was further employed for real-Time monitoring of the triggered dynamic change of the intracellular H2S level in live cells.",

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AU - Li, Nan

AU - Than, Aung

AU - Chen, Jie

AU - Xi, Fengna

AU - Liu, Jiyang

AU - Chen, Peng

N1 - Publisher Copyright: © The Royal Society of Chemistry.

PY - 2018/4

Y1 - 2018/4

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AB - Hydrogen sulfide (H2S), being an important gaseous signaling molecule, has been gaining increasing attention for its involvement in a wide range of physiological processes. Herein, we developed a novel fluorescence turn-on nanoprobe for selective and sensitive detection of H2S based on graphene quantum dots (GQDs) conjugated with (2,4-dinitrophenoxy)tyrosine (DNPTYR). Taking advantage of its high fluorescence quantum yield, biocompatibility, photostability, and ease to be uptaken by cells, the GQD-based fluorescence probe was further employed for real-Time monitoring of the triggered dynamic change of the intracellular H2S level in live cells.

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Graphene quantum dots based fluorescence turn-on nanoprobe for highly sensitive and selective imaging of hydrogen sulfide in living cells

Abstract

Bibliographical note

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