Group VIII Metal Carbonyl Cluster-Boronic Acid Conjugates: Cytotoxicity and Mode of Action Studies

Jia Wen Kong; Zhiyong Lam; Kiat Hwa Chan; Rakesh Ganguly; Jia Ying Joey Lee; Lit Hsin Loo; Richard D. Webster; Zhen Xuan Wong; Weng Kee Leong

doi:10.1021/acsomega.1c04116

Group VIII Metal Carbonyl Cluster-Boronic Acid Conjugates: Cytotoxicity and Mode of Action Studies

Jia Wen Kong, Zhiyong Lam, Kiat Hwa Chan, Rakesh Ganguly, Jia Ying Joey Lee, Lit Hsin Loo, Richard D. Webster, Zhen Xuan Wong, Weng Kee Leong^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

A set of metal carbonyl cluster-boronic acid conjugates of the group VIII metals (Fe, Ru, and Os) were synthesized and their antiproliferative effects measured against two breast cancer cell lines (MCF-7 and MDA-MB-231) and a noncancerous breast epithelial (MCF-10A) cell line. The cytotoxicity followed the order Ru > Os > Fe for the MDA-MB-231 cells, although the latter two exhibited similar cytotoxicity against MCF-7 and MCF-10A cells. The osmium species {Os3(CO)10(μ-H)[μ-SC6H4-p-B(OH)2]} (2) could be chemically oxidized to its hydroxy analogue [Os3(CO)10(μ-H)(μ-SC6H4-p-OH)] (2-OH), which showed comparable cytotoxicity. Mode of action studies pointed to an apoptotic pathway for cell death.

Original language	English
Pages (from-to)	29045-29053
Number of pages	9
Journal	ACS Omega
Volume	6
Issue number	43
DOIs	https://doi.org/10.1021/acsomega.1c04116
Publication status	Published - Nov 2 2021
Externally published	Yes

Bibliographical note

Publisher Copyright:
©

ASJC Scopus Subject Areas

General Chemistry
General Chemical Engineering

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1021/acsomega.1c04116

Cite this

@article{0d78fc2776fe4bcf81384e2f78465931,

title = "Group VIII Metal Carbonyl Cluster-Boronic Acid Conjugates: Cytotoxicity and Mode of Action Studies",

abstract = "A set of metal carbonyl cluster-boronic acid conjugates of the group VIII metals (Fe, Ru, and Os) were synthesized and their antiproliferative effects measured against two breast cancer cell lines (MCF-7 and MDA-MB-231) and a noncancerous breast epithelial (MCF-10A) cell line. The cytotoxicity followed the order Ru > Os > Fe for the MDA-MB-231 cells, although the latter two exhibited similar cytotoxicity against MCF-7 and MCF-10A cells. The osmium species {Os3(CO)10(μ-H)[μ-SC6H4-p-B(OH)2]} (2) could be chemically oxidized to its hydroxy analogue [Os3(CO)10(μ-H)(μ-SC6H4-p-OH)] (2-OH), which showed comparable cytotoxicity. Mode of action studies pointed to an apoptotic pathway for cell death.",

author = "Kong, {Jia Wen} and Zhiyong Lam and Chan, {Kiat Hwa} and Rakesh Ganguly and {Joey Lee}, {Jia Ying} and Loo, {Lit Hsin} and Webster, {Richard D.} and Wong, {Zhen Xuan} and Leong, {Weng Kee}",

note = "Publisher Copyright: {\textcopyright} ",

year = "2021",

month = nov,

day = "2",

doi = "10.1021/acsomega.1c04116",

language = "English",

volume = "6",

pages = "29045--29053",

journal = "ACS Omega",

issn = "2470-1343",

publisher = "American Chemical Society",

number = "43",

}

TY - JOUR

T1 - Group VIII Metal Carbonyl Cluster-Boronic Acid Conjugates

T2 - Cytotoxicity and Mode of Action Studies

AU - Kong, Jia Wen

AU - Lam, Zhiyong

AU - Chan, Kiat Hwa

AU - Ganguly, Rakesh

AU - Joey Lee, Jia Ying

AU - Loo, Lit Hsin

AU - Webster, Richard D.

AU - Wong, Zhen Xuan

AU - Leong, Weng Kee

PY - 2021/11/2

Y1 - 2021/11/2

N2 - A set of metal carbonyl cluster-boronic acid conjugates of the group VIII metals (Fe, Ru, and Os) were synthesized and their antiproliferative effects measured against two breast cancer cell lines (MCF-7 and MDA-MB-231) and a noncancerous breast epithelial (MCF-10A) cell line. The cytotoxicity followed the order Ru > Os > Fe for the MDA-MB-231 cells, although the latter two exhibited similar cytotoxicity against MCF-7 and MCF-10A cells. The osmium species {Os3(CO)10(μ-H)[μ-SC6H4-p-B(OH)2]} (2) could be chemically oxidized to its hydroxy analogue [Os3(CO)10(μ-H)(μ-SC6H4-p-OH)] (2-OH), which showed comparable cytotoxicity. Mode of action studies pointed to an apoptotic pathway for cell death.

AB - A set of metal carbonyl cluster-boronic acid conjugates of the group VIII metals (Fe, Ru, and Os) were synthesized and their antiproliferative effects measured against two breast cancer cell lines (MCF-7 and MDA-MB-231) and a noncancerous breast epithelial (MCF-10A) cell line. The cytotoxicity followed the order Ru > Os > Fe for the MDA-MB-231 cells, although the latter two exhibited similar cytotoxicity against MCF-7 and MCF-10A cells. The osmium species {Os3(CO)10(μ-H)[μ-SC6H4-p-B(OH)2]} (2) could be chemically oxidized to its hydroxy analogue [Os3(CO)10(μ-H)(μ-SC6H4-p-OH)] (2-OH), which showed comparable cytotoxicity. Mode of action studies pointed to an apoptotic pathway for cell death.

UR - http://www.scopus.com/inward/record.url?scp=85118621391&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85118621391&partnerID=8YFLogxK

U2 - 10.1021/acsomega.1c04116

DO - 10.1021/acsomega.1c04116

M3 - Article

AN - SCOPUS:85118621391

SN - 2470-1343

VL - 6

SP - 29045

EP - 29053

JO - ACS Omega

JF - ACS Omega

IS - 43

ER -

Group VIII Metal Carbonyl Cluster-Boronic Acid Conjugates: Cytotoxicity and Mode of Action Studies

Abstract

Bibliographical note

ASJC Scopus Subject Areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this