Gut microbiome modulates the toxicity of hydrazine: A metabonomic study

Jonathan Swann; Yulan Wang; Leticia Abecia; Adele Costabile; Kieran Tuohy; Glenn Gibson; David Roberts; James Sidaway; Huw Jones; Ian D. Wilson; Jeremy Nicholson; Elaine Holmes

doi:10.1039/b811468d

Gut microbiome modulates the toxicity of hydrazine: A metabonomic study

Jonathan Swann, Yulan Wang, Leticia Abecia, Adele Costabile, Kieran Tuohy, Glenn Gibson, David Roberts, James Sidaway, Huw Jones, Ian D. Wilson, Jeremy Nicholson, Elaine Holmes^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

57 Citations (Scopus)

Abstract

The influence of gut microbiota on the toxicity and metabolism of hydrazine has been investigated in germ-free and 'conventional' Sprague Dawley rats using ¹H NMR based metabonomic analysis of urine and plasma. Toxicity was more severe in germ-free rats compared with conventional rats for equivalent exposures indicating that bacterial presence altered the nature or extent of response to hydrazine and that the toxic response can vary markedly in the absence of a functional microbiome.

Original language	English
Pages (from-to)	351-355
Number of pages	5
Journal	Molecular BioSystems
Volume	5
Issue number	4
DOIs	https://doi.org/10.1039/b811468d
Publication status	Published - 2009
Externally published	Yes

ASJC Scopus Subject Areas

Biotechnology
Molecular Biology

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10.1039/b811468d

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title = "Gut microbiome modulates the toxicity of hydrazine: A metabonomic study",

abstract = "The influence of gut microbiota on the toxicity and metabolism of hydrazine has been investigated in germ-free and 'conventional' Sprague Dawley rats using 1H NMR based metabonomic analysis of urine and plasma. Toxicity was more severe in germ-free rats compared with conventional rats for equivalent exposures indicating that bacterial presence altered the nature or extent of response to hydrazine and that the toxic response can vary markedly in the absence of a functional microbiome.",

author = "Jonathan Swann and Yulan Wang and Leticia Abecia and Adele Costabile and Kieran Tuohy and Glenn Gibson and David Roberts and James Sidaway and Huw Jones and Wilson, {Ian D.} and Jeremy Nicholson and Elaine Holmes",

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journal = "Molecular BioSystems",

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T2 - A metabonomic study

AU - Swann, Jonathan

AU - Wang, Yulan

AU - Abecia, Leticia

AU - Costabile, Adele

AU - Tuohy, Kieran

AU - Gibson, Glenn

AU - Roberts, David

AU - Sidaway, James

AU - Jones, Huw

AU - Wilson, Ian D.

AU - Nicholson, Jeremy

AU - Holmes, Elaine

PY - 2009

Y1 - 2009

N2 - The influence of gut microbiota on the toxicity and metabolism of hydrazine has been investigated in germ-free and 'conventional' Sprague Dawley rats using 1H NMR based metabonomic analysis of urine and plasma. Toxicity was more severe in germ-free rats compared with conventional rats for equivalent exposures indicating that bacterial presence altered the nature or extent of response to hydrazine and that the toxic response can vary markedly in the absence of a functional microbiome.

AB - The influence of gut microbiota on the toxicity and metabolism of hydrazine has been investigated in germ-free and 'conventional' Sprague Dawley rats using 1H NMR based metabonomic analysis of urine and plasma. Toxicity was more severe in germ-free rats compared with conventional rats for equivalent exposures indicating that bacterial presence altered the nature or extent of response to hydrazine and that the toxic response can vary markedly in the absence of a functional microbiome.

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SP - 351

EP - 355

JO - Molecular BioSystems

JF - Molecular BioSystems

IS - 4

ER -

Gut microbiome modulates the toxicity of hydrazine: A metabonomic study

Abstract

ASJC Scopus Subject Areas

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