Harnessing Croconaine Organic Photosensitizers for a Milder Surface-Mediated Transfection

Ferdinandus; Wen Ling Lenice Tan; Jie Ren Tan; Hiang Kwee Lee; Qiang Zhu; Enyi Ye; Chi Lik Ken Lee

doi:10.1002/asia.202400328

Harnessing Croconaine Organic Photosensitizers for a Milder Surface-Mediated Transfection

Ferdinandus, Wen Ling Lenice Tan, Jie Ren Tan, Hiang Kwee Lee^*, Qiang Zhu, Enyi Ye, Chi Lik Ken Lee^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

Polydopamine-based materials, notably Polydopamine-polyethyleneimine (PDA-PEI), have gained considerable interest for surface-mediated transfection. However, the high laser power density required to achieve high transfection efficiency poses a significant challenge in preserving cell viability. An organic photosensitizer CRO32TMI was developed to improve the photothermal conversion capability of PDA-PEI. The modified PDA-PEI-CRO32TMI exhibited remarkable photothermal and photostability properties upon NIR irradiation, enabling it to achieve better transfection efficiency at lower laser power density as compared to the traditional solution or lipid-based transfection methods.

Original language	English
Article number	e202400328
Journal	Chemistry - An Asian Journal
Volume	19
Issue number	14
DOIs	https://doi.org/10.1002/asia.202400328
Publication status	Published - Jul 15 2024
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2024 Wiley-VCH GmbH.

ASJC Scopus Subject Areas

Biochemistry
General Chemistry
Organic Chemistry

Keywords

organic photosensitizer
photothermal
transfection

Access to Document

10.1002/asia.202400328

Cite this

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title = "Harnessing Croconaine Organic Photosensitizers for a Milder Surface-Mediated Transfection",

abstract = "Polydopamine-based materials, notably Polydopamine-polyethyleneimine (PDA-PEI), have gained considerable interest for surface-mediated transfection. However, the high laser power density required to achieve high transfection efficiency poses a significant challenge in preserving cell viability. An organic photosensitizer CRO32TMI was developed to improve the photothermal conversion capability of PDA-PEI. The modified PDA-PEI-CRO32TMI exhibited remarkable photothermal and photostability properties upon NIR irradiation, enabling it to achieve better transfection efficiency at lower laser power density as compared to the traditional solution or lipid-based transfection methods.",

keywords = "organic photosensitizer, photothermal, transfection",

author = "Ferdinandus and Tan, {Wen Ling Lenice} and Tan, {Jie Ren} and Lee, {Hiang Kwee} and Qiang Zhu and Enyi Ye and Lee, {Chi Lik Ken}",

note = "Publisher Copyright: {\textcopyright} 2024 Wiley-VCH GmbH.",

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doi = "10.1002/asia.202400328",

language = "English",

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AU - Ferdinandus,

AU - Tan, Wen Ling Lenice

AU - Tan, Jie Ren

AU - Lee, Hiang Kwee

AU - Zhu, Qiang

AU - Ye, Enyi

AU - Lee, Chi Lik Ken

PY - 2024/7/15

Y1 - 2024/7/15

N2 - Polydopamine-based materials, notably Polydopamine-polyethyleneimine (PDA-PEI), have gained considerable interest for surface-mediated transfection. However, the high laser power density required to achieve high transfection efficiency poses a significant challenge in preserving cell viability. An organic photosensitizer CRO32TMI was developed to improve the photothermal conversion capability of PDA-PEI. The modified PDA-PEI-CRO32TMI exhibited remarkable photothermal and photostability properties upon NIR irradiation, enabling it to achieve better transfection efficiency at lower laser power density as compared to the traditional solution or lipid-based transfection methods.

AB - Polydopamine-based materials, notably Polydopamine-polyethyleneimine (PDA-PEI), have gained considerable interest for surface-mediated transfection. However, the high laser power density required to achieve high transfection efficiency poses a significant challenge in preserving cell viability. An organic photosensitizer CRO32TMI was developed to improve the photothermal conversion capability of PDA-PEI. The modified PDA-PEI-CRO32TMI exhibited remarkable photothermal and photostability properties upon NIR irradiation, enabling it to achieve better transfection efficiency at lower laser power density as compared to the traditional solution or lipid-based transfection methods.

KW - organic photosensitizer

KW - photothermal

KW - transfection

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Harnessing Croconaine Organic Photosensitizers for a Milder Surface-Mediated Transfection

Abstract

Bibliographical note

ASJC Scopus Subject Areas

Keywords

Access to Document

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