Abstract
Molecular activatable probes with near-infrared (NIR) fluorescence play a critical role in in vivo imaging of biomarkers for drug screening and disease diagnosis. With structural diversity and high fluorescence quantum yields, hemicyanine dyes have emerged as a versatile scaffold for the construction of activatable optical probes. This Review presents a survey of hemicyanine-based NIR activatable probes (HNAPs) for in vivo imaging and early diagnosis of diseases. The molecular design principles of HNAPs towards activatable optical signaling against various biomarkers are discussed with a focus on their broad applications in the detection of diseases including inflammation, acute organ failure, skin diseases, intestinal diseases, and cancer. This progress not only proves the unique value of HNAPs in preclinical research but also highlights their high translational potential in clinical diagnosis.
| Original language | English |
|---|---|
| Pages (from-to) | 26454-26475 |
| Number of pages | 22 |
| Journal | Angewandte Chemie - International Edition |
| Volume | 60 |
| Issue number | 51 |
| DOIs | |
| Publication status | Published - Dec 13 2021 |
| Externally published | Yes |
Bibliographical note
Publisher Copyright:© 2021 Wiley-VCH GmbH
ASJC Scopus Subject Areas
- Catalysis
- General Chemistry
Keywords
- activatable probes
- disease diagnosis
- fluorescent probes
- hemicyanines
- optical imaging
