High nuclearity carbonyl clusters as near-IR contrast agents for photoacoustic: In vivo imaging

Zhiyong Lam; Ghayathri Balasundaram; Kien Voon Kong; Bo Yang Chor; Douglas Goh; Bahareh Khezri; Richard D. Webster; Weng Kee Leong; Malini Olivo

doi:10.1039/c6tb00075d

High nuclearity carbonyl clusters as near-IR contrast agents for photoacoustic: In vivo imaging

Zhiyong Lam, Ghayathri Balasundaram, Kien Voon Kong, Bo Yang Chor, Douglas Goh, Bahareh Khezri, Richard D. Webster, Weng Kee Leong^*, Malini Olivo

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

High nuclearity carbonyl clusters of ruthenium and osmium are found to exhibit good photoacoustic (PA) activity in the near-IR (NIR) region. Their potential as PA contrast agents for full body imaging has been demonstrated for the first time with mice; intravenous administration of the osmium carbonyl cluster Na₂[Os₁₀(μ₆-C)(CO)₂₄] afforded up to a four-fold enhancement of the PA signal in various tissues. The cluster exhibits low toxicity, high stability and superior PA stability compared to the clinically approved NIR dye, indocyanine green.

Original language	English
Pages (from-to)	3886-3891
Number of pages	6
Journal	Journal of Materials Chemistry B
Volume	4
Issue number	22
DOIs	https://doi.org/10.1039/c6tb00075d
Publication status	Published - 2016
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2016 The Royal Society of Chemistry.

ASJC Scopus Subject Areas

General Chemistry
Biomedical Engineering
General Materials Science

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abstract = "High nuclearity carbonyl clusters of ruthenium and osmium are found to exhibit good photoacoustic (PA) activity in the near-IR (NIR) region. Their potential as PA contrast agents for full body imaging has been demonstrated for the first time with mice; intravenous administration of the osmium carbonyl cluster Na2[Os10(μ6-C)(CO)24] afforded up to a four-fold enhancement of the PA signal in various tissues. The cluster exhibits low toxicity, high stability and superior PA stability compared to the clinically approved NIR dye, indocyanine green.",

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doi = "10.1039/c6tb00075d",

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T1 - High nuclearity carbonyl clusters as near-IR contrast agents for photoacoustic

T2 - In vivo imaging

AU - Lam, Zhiyong

AU - Balasundaram, Ghayathri

AU - Kong, Kien Voon

AU - Chor, Bo Yang

AU - Goh, Douglas

AU - Khezri, Bahareh

AU - Webster, Richard D.

AU - Leong, Weng Kee

AU - Olivo, Malini

PY - 2016

Y1 - 2016

N2 - High nuclearity carbonyl clusters of ruthenium and osmium are found to exhibit good photoacoustic (PA) activity in the near-IR (NIR) region. Their potential as PA contrast agents for full body imaging has been demonstrated for the first time with mice; intravenous administration of the osmium carbonyl cluster Na2[Os10(μ6-C)(CO)24] afforded up to a four-fold enhancement of the PA signal in various tissues. The cluster exhibits low toxicity, high stability and superior PA stability compared to the clinically approved NIR dye, indocyanine green.

AB - High nuclearity carbonyl clusters of ruthenium and osmium are found to exhibit good photoacoustic (PA) activity in the near-IR (NIR) region. Their potential as PA contrast agents for full body imaging has been demonstrated for the first time with mice; intravenous administration of the osmium carbonyl cluster Na2[Os10(μ6-C)(CO)24] afforded up to a four-fold enhancement of the PA signal in various tissues. The cluster exhibits low toxicity, high stability and superior PA stability compared to the clinically approved NIR dye, indocyanine green.

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High nuclearity carbonyl clusters as near-IR contrast agents for photoacoustic: In vivo imaging

Abstract

Bibliographical note

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