@inproceedings{813031d57f964256b30c2aed36a9a7ff,
title = "High-resolution Dean Flow Fractionation (HiDFF): A novel dean migration phenomenon for small microparticle separation",
abstract = "Inertial focusing of small microparticles (< 1-2 μm) in microfluidics remains a technical challenge as channel dimensions have to be scaled down significantly to experience sufficient inertial forces (FL) for lateral migration. Herein, we introduce a novel Dean migration phenomenon in spiral microchannel, termed as High-resolution Dean Flow Fractionation (HiDFF), for high throughput separation of small microparticles based on differential Dean migration profiles. Efficient separation of 1-3 μm beads mixture was demonstrated using HiDFF. The developed technology was used to size-fractionate different small biological components, including bacteria and drug-loaded nanoparticles (NPs) with superior resolution (∼1 μm) and throughput (∼100 μlmin-1).",
keywords = "Cell separation, Dean Flow, Inertial microfluidics, Nanoparticles",
author = "Tay, {Hui Min} and Tan, {Kah Kee} and Sharad Kharel and Loo, {Say Chye Joachim} and Hou, {Han Wei}",
year = "2016",
language = "English",
series = "20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016",
publisher = "Chemical and Biological Microsystems Society",
pages = "1519--1520",
booktitle = "20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016",
note = "20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016 ; Conference date: 09-10-2016 Through 13-10-2016",
}