High throughput quantification of protein expression of cancer antigens in tissue microarray using quantum dot nanocrystals

Arezou A. Ghazani; Jeongjin A. Lee; Jesse Klostranec; Qing Xiang; Ralph S. Dacosta; Brian C. Wilson; Ming S. Tsao; Warren C.W. Chan

doi:10.1021/nl062111n

High throughput quantification of protein expression of cancer antigens in tissue microarray using quantum dot nanocrystals

Arezou A. Ghazani, Jeongjin A. Lee, Jesse Klostranec, Qing Xiang, Ralph S. Dacosta, Brian C. Wilson, Ming S. Tsao, Warren C.W. Chan^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

109 Citations (Scopus)

Abstract

We developed and validated a novel method for quantifying protein expression of cancer tumors in an accurate, sensitive, and high throughput format. This technique integrates quantum dots, tissue microarray, optical spectroscopy, and algorithm design for analysis of tumor biopsies. The integration of this method for tissue analysis in the clinic bears potential impact for improving the diagnosis and treatment of cancer.

Original language	English
Pages (from-to)	2881-2886
Number of pages	6
Journal	Nano Letters
Volume	6
Issue number	12
DOIs	https://doi.org/10.1021/nl062111n
Publication status	Published - Dec 2006
Externally published	Yes

ASJC Scopus Subject Areas

Bioengineering
General Chemistry
General Materials Science
Condensed Matter Physics
Mechanical Engineering

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1021/nl062111n

Cite this

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title = "High throughput quantification of protein expression of cancer antigens in tissue microarray using quantum dot nanocrystals",

abstract = "We developed and validated a novel method for quantifying protein expression of cancer tumors in an accurate, sensitive, and high throughput format. This technique integrates quantum dots, tissue microarray, optical spectroscopy, and algorithm design for analysis of tumor biopsies. The integration of this method for tissue analysis in the clinic bears potential impact for improving the diagnosis and treatment of cancer.",

author = "Ghazani, {Arezou A.} and Lee, {Jeongjin A.} and Jesse Klostranec and Qing Xiang and Dacosta, {Ralph S.} and Wilson, {Brian C.} and Tsao, {Ming S.} and Chan, {Warren C.W.}",

year = "2006",

month = dec,

doi = "10.1021/nl062111n",

language = "English",

volume = "6",

pages = "2881--2886",

journal = "Nano Letters",

issn = "1530-6984",

publisher = "American Chemical Society",

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TY - JOUR

T1 - High throughput quantification of protein expression of cancer antigens in tissue microarray using quantum dot nanocrystals

AU - Ghazani, Arezou A.

AU - Lee, Jeongjin A.

AU - Klostranec, Jesse

AU - Xiang, Qing

AU - Dacosta, Ralph S.

AU - Wilson, Brian C.

AU - Tsao, Ming S.

AU - Chan, Warren C.W.

PY - 2006/12

Y1 - 2006/12

N2 - We developed and validated a novel method for quantifying protein expression of cancer tumors in an accurate, sensitive, and high throughput format. This technique integrates quantum dots, tissue microarray, optical spectroscopy, and algorithm design for analysis of tumor biopsies. The integration of this method for tissue analysis in the clinic bears potential impact for improving the diagnosis and treatment of cancer.

AB - We developed and validated a novel method for quantifying protein expression of cancer tumors in an accurate, sensitive, and high throughput format. This technique integrates quantum dots, tissue microarray, optical spectroscopy, and algorithm design for analysis of tumor biopsies. The integration of this method for tissue analysis in the clinic bears potential impact for improving the diagnosis and treatment of cancer.

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U2 - 10.1021/nl062111n

DO - 10.1021/nl062111n

M3 - Article

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AN - SCOPUS:33846342579

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JO - Nano Letters

JF - Nano Letters

IS - 12

ER -

High throughput quantification of protein expression of cancer antigens in tissue microarray using quantum dot nanocrystals

Abstract

ASJC Scopus Subject Areas

UN SDGs

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