TY - JOUR
T1 - Impact of amphiphilic triblock copolymers on stability and permeability of phospholipid/polymer hybrid vesicles
AU - Shen, Wenming
AU - Hu, Jinhua
AU - Hu, Xiao
PY - 2014/4/29
Y1 - 2014/4/29
N2 - This Letter seeks to understand the impact of ABA amphiphilic copolymers on liposomes concerning their stability, bilayer permeability and bilayer phase transition. Results show that the hybrid vesicles have substantially increased shelf stability, resistance against rupture and fusion, and unique permeation behavior. Discussion is carried out on the possible mechanisms associated with bilayer structural changes, which the hydrophobic B block of the copolymer serves as a spacer and fills the voids between the lipids and the hydrophilic A block provides 'arms' in the aqueous phase. A longer hydrophilic chain length provided enhanced vesicle stability relative to a shorter chain length.
AB - This Letter seeks to understand the impact of ABA amphiphilic copolymers on liposomes concerning their stability, bilayer permeability and bilayer phase transition. Results show that the hybrid vesicles have substantially increased shelf stability, resistance against rupture and fusion, and unique permeation behavior. Discussion is carried out on the possible mechanisms associated with bilayer structural changes, which the hydrophobic B block of the copolymer serves as a spacer and fills the voids between the lipids and the hydrophilic A block provides 'arms' in the aqueous phase. A longer hydrophilic chain length provided enhanced vesicle stability relative to a shorter chain length.
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U2 - 10.1016/j.cplett.2014.03.057
DO - 10.1016/j.cplett.2014.03.057
M3 - Article
AN - SCOPUS:84898652703
SN - 0009-2614
VL - 600
SP - 56
EP - 61
JO - Chemical Physics Letters
JF - Chemical Physics Letters
ER -