Impact of Tumor Barriers on Nanoparticle Delivery to Macrophages

Ben Ouyang; Benjamin R. Kingston; Wilson Poon; Yi Nan Zhang; Zachary P. Lin; Abdullah M. Syed; Julien Couture-Senécal; Warren C.W. Chan

doi:10.1021/acs.molpharmaceut.1c00905

Impact of Tumor Barriers on Nanoparticle Delivery to Macrophages

Ben Ouyang, Benjamin R. Kingston, Wilson Poon, Yi Nan Zhang, Zachary P. Lin, Abdullah M. Syed, Julien Couture-Senécal, Warren C.W. Chan^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

The delivery of therapeutic nanoparticles to target cells is critical to their effectiveness. Here we quantified the impact of biological barriers on the delivery of nanoparticles to macrophages in two different tissues. We compared the delivery of gold nanoparticles to macrophages in the liver versus those in the tumor. We found that nanoparticle delivery to macrophages in the tumor was 75% less than to macrophages in the liver due to structural barriers. The tumor-associated macrophages took up more nanoparticles than Kupffer cells in the absence of barriers. Our results highlight the impact of biological barriers on nanoparticle delivery to cellular targets.

Original language	English
Pages (from-to)	1917-1925
Number of pages	9
Journal	Molecular Pharmaceutics
Volume	19
Issue number	6
DOIs	https://doi.org/10.1021/acs.molpharmaceut.1c00905
Publication status	Published - Jun 6 2022
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2022 American Chemical Society. All rights reserved.

ASJC Scopus Subject Areas

Molecular Medicine
Pharmaceutical Science
Drug Discovery

Keywords

cancer
delivery
gold
macrophage
nanoparticle
tumor

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1021/acs.molpharmaceut.1c00905

Cite this

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abstract = "The delivery of therapeutic nanoparticles to target cells is critical to their effectiveness. Here we quantified the impact of biological barriers on the delivery of nanoparticles to macrophages in two different tissues. We compared the delivery of gold nanoparticles to macrophages in the liver versus those in the tumor. We found that nanoparticle delivery to macrophages in the tumor was 75% less than to macrophages in the liver due to structural barriers. The tumor-associated macrophages took up more nanoparticles than Kupffer cells in the absence of barriers. Our results highlight the impact of biological barriers on nanoparticle delivery to cellular targets.",

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AU - Ouyang, Ben

AU - Kingston, Benjamin R.

AU - Poon, Wilson

AU - Zhang, Yi Nan

AU - Lin, Zachary P.

AU - Syed, Abdullah M.

AU - Couture-Senécal, Julien

AU - Chan, Warren C.W.

PY - 2022/6/6

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N2 - The delivery of therapeutic nanoparticles to target cells is critical to their effectiveness. Here we quantified the impact of biological barriers on the delivery of nanoparticles to macrophages in two different tissues. We compared the delivery of gold nanoparticles to macrophages in the liver versus those in the tumor. We found that nanoparticle delivery to macrophages in the tumor was 75% less than to macrophages in the liver due to structural barriers. The tumor-associated macrophages took up more nanoparticles than Kupffer cells in the absence of barriers. Our results highlight the impact of biological barriers on nanoparticle delivery to cellular targets.

AB - The delivery of therapeutic nanoparticles to target cells is critical to their effectiveness. Here we quantified the impact of biological barriers on the delivery of nanoparticles to macrophages in two different tissues. We compared the delivery of gold nanoparticles to macrophages in the liver versus those in the tumor. We found that nanoparticle delivery to macrophages in the tumor was 75% less than to macrophages in the liver due to structural barriers. The tumor-associated macrophages took up more nanoparticles than Kupffer cells in the absence of barriers. Our results highlight the impact of biological barriers on nanoparticle delivery to cellular targets.

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KW - delivery

KW - gold

KW - macrophage

KW - nanoparticle

KW - tumor

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Impact of Tumor Barriers on Nanoparticle Delivery to Macrophages

Abstract

Bibliographical note

ASJC Scopus Subject Areas

Keywords

UN SDGs

Access to Document

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