In Vitro and in Vivo Photothermal Cancer Therapeutic Effects of Gold Nanorods Modified with Mushroom β-Glucan

Xiaojie Li; Jiajing Zhou; Xiaonan Dong; Wai Yin Cheng; Hongwei Duan; Peter C.K. Cheung

doi:10.1021/acs.jafc.8b00292

In Vitro and in Vivo Photothermal Cancer Therapeutic Effects of Gold Nanorods Modified with Mushroom β-Glucan

Xiaojie Li, Jiajing Zhou, Xiaonan Dong, Wai Yin Cheng, Hongwei Duan^*, Peter C.K. Cheung

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

43 Citations (Scopus)

Abstract

The photothermal cancer therapeutic effect of the AuNR-Glu nanohybrids produced by coating native gold nanorods (AuNRs) with a natural mushroom biopolymer from the Pleurotus tuber-regium sclerotia (Glu) were studied in the second near-infrared window (NIR-II). The AuNR-Glu exhibited low cytotoxicity and high biocompatibility due to the surface modification of Glu when compared with the native AuNRs. AuNR-Glu nanohybrids had a high photothermal transduction efficiency (η) of 43.12%, causing effective in vitro cell ablation in both HT-29 (94.2 ± 0.8% cell death) and SW480 (94.8 ± 1.1% cell death) colon cancer cells under 1064 nm NIR-II laser irradiation at 1.0 W/cm². Intravenous injection of AuNR-Glu nanohybrids followed by irradiation from a NIR-II laser at a safe dose (1.0 W/cm² for 5 min) in nude mice implanted with HT-29 tumors was effective in significantly reducing the tumor growth, with no obvious harmful side effects, as evidenced by histological analysis of major organs. The present results have shown that AuNRs modified by natural biopolymers from mushroom β-glucans are novel nanomaterials with low cytotoxicity and effective photothermal anticancer agents with potential biomedical applications.

Original language	English
Pages (from-to)	4091-4098
Number of pages	8
Journal	Journal of Agricultural and Food Chemistry
Volume	66
Issue number	16
DOIs	https://doi.org/10.1021/acs.jafc.8b00292
Publication status	Published - Apr 25 2018
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2018 American Chemical Society.

ASJC Scopus Subject Areas

General Chemistry
General Agricultural and Biological Sciences

Keywords

gold nanorods
mushroom β-glucan
photothermal therapy
second near-infrared radiation
surface modification

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1021/acs.jafc.8b00292

Cite this

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title = "In Vitro and in Vivo Photothermal Cancer Therapeutic Effects of Gold Nanorods Modified with Mushroom β-Glucan",

abstract = "The photothermal cancer therapeutic effect of the AuNR-Glu nanohybrids produced by coating native gold nanorods (AuNRs) with a natural mushroom biopolymer from the Pleurotus tuber-regium sclerotia (Glu) were studied in the second near-infrared window (NIR-II). The AuNR-Glu exhibited low cytotoxicity and high biocompatibility due to the surface modification of Glu when compared with the native AuNRs. AuNR-Glu nanohybrids had a high photothermal transduction efficiency (η) of 43.12%, causing effective in vitro cell ablation in both HT-29 (94.2 ± 0.8% cell death) and SW480 (94.8 ± 1.1% cell death) colon cancer cells under 1064 nm NIR-II laser irradiation at 1.0 W/cm2. Intravenous injection of AuNR-Glu nanohybrids followed by irradiation from a NIR-II laser at a safe dose (1.0 W/cm2 for 5 min) in nude mice implanted with HT-29 tumors was effective in significantly reducing the tumor growth, with no obvious harmful side effects, as evidenced by histological analysis of major organs. The present results have shown that AuNRs modified by natural biopolymers from mushroom β-glucans are novel nanomaterials with low cytotoxicity and effective photothermal anticancer agents with potential biomedical applications.",

keywords = "gold nanorods, mushroom β-glucan, photothermal therapy, second near-infrared radiation, surface modification",

author = "Xiaojie Li and Jiajing Zhou and Xiaonan Dong and Cheng, {Wai Yin} and Hongwei Duan and Cheung, {Peter C.K.}",

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doi = "10.1021/acs.jafc.8b00292",

language = "English",

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AU - Li, Xiaojie

AU - Zhou, Jiajing

AU - Dong, Xiaonan

AU - Cheng, Wai Yin

AU - Duan, Hongwei

AU - Cheung, Peter C.K.

PY - 2018/4/25

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KW - second near-infrared radiation

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In Vitro and in Vivo Photothermal Cancer Therapeutic Effects of Gold Nanorods Modified with Mushroom β-Glucan

Abstract

Bibliographical note

ASJC Scopus Subject Areas

Keywords

UN SDGs

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