In vitro cytotoxicities of ionic liquids: Effect of cation rings, functional groups, and anions

R. Anand Kumar; Nicolas Papaïconomou; Jong Min Lee; Justin Salminen; Douglas S. Clark; John M. Prausnitz

doi:10.1002/tox.20443

In vitro cytotoxicities of ionic liquids: Effect of cation rings, functional groups, and anions

R. Anand Kumar, Nicolas Papaïconomou, Jong Min Lee, Justin Salminen, Douglas S. Clark, John M. Prausnitz

Research output: Contribution to journal › Article › peer-review

151 Citations (Scopus)

Abstract

In vitro cytotoxicities were measured for ionic liquids (ILs) containing various cations and anions using the MCF7 human breast cancer cell line. We measured the cytotoxicities of ionic liquids containing the cations pyridinium, pyrrolidinium, piperidinium, or imidazolium with various alkyl chain lengths, and the anions bromide, bis(trifluoromethanesulfone)imide (Tf₂N), trifluoromethylsulfonate (TfO), or non-afluoromethylsulfonate (NfO). Three new hydrophobic, task-specific ionic liquids (TSILs), namely, [MBCNPip] ⁺[Tf₂N]^-, [MPS₂Pip] ⁺[Tf₂N]^-, and [MPS₂Pyrro] ⁺[Tf₂N]^- designed for metal-ion extraction were also evaluated. IC₅₀ values of the ionic liquids toward the MCF7 cells ranged from 8 μM to 44 mM. The toxicity depended significantly on the nature of the cations and anions, especially when the cations contained a long side chain. TSILs studied in this work were less toxic than the classical ILs.

Original language	English
Pages (from-to)	388-395
Number of pages	8
Journal	Environmental Toxicology
Volume	24
Issue number	4
DOIs	https://doi.org/10.1002/tox.20443
Publication status	Published - Aug 2009
Externally published	Yes

ASJC Scopus Subject Areas

Toxicology
Management, Monitoring, Policy and Law
Health, Toxicology and Mutagenesis

Keywords

Cytotoxicity
Ionic liquids
Task-specific ionic liquids

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1002/tox.20443

Cite this

@article{69f63d2bb58c4956b8cc4280ac123e9f,

title = "In vitro cytotoxicities of ionic liquids: Effect of cation rings, functional groups, and anions",

abstract = "In vitro cytotoxicities were measured for ionic liquids (ILs) containing various cations and anions using the MCF7 human breast cancer cell line. We measured the cytotoxicities of ionic liquids containing the cations pyridinium, pyrrolidinium, piperidinium, or imidazolium with various alkyl chain lengths, and the anions bromide, bis(trifluoromethanesulfone)imide (Tf2N), trifluoromethylsulfonate (TfO), or non-afluoromethylsulfonate (NfO). Three new hydrophobic, task-specific ionic liquids (TSILs), namely, [MBCNPip] +[Tf2N]-, [MPS2Pip] +[Tf2N]-, and [MPS2Pyrro] +[Tf2N]- designed for metal-ion extraction were also evaluated. IC50 values of the ionic liquids toward the MCF7 cells ranged from 8 μM to 44 mM. The toxicity depended significantly on the nature of the cations and anions, especially when the cations contained a long side chain. TSILs studied in this work were less toxic than the classical ILs.",

keywords = "Cytotoxicity, Ionic liquids, Task-specific ionic liquids",

author = "Kumar, \{R. Anand\} and Nicolas Papa{\"i}conomou and Lee, \{Jong Min\} and Justin Salminen and Clark, \{Douglas S.\} and Prausnitz, \{John M.\}",

year = "2009",

month = aug,

doi = "10.1002/tox.20443",

language = "English",

volume = "24",

pages = "388--395",

journal = "Environmental Toxicology",

issn = "1520-4081",

publisher = "John Wiley and Sons Inc.",

number = "4",

}

TY - JOUR

T1 - In vitro cytotoxicities of ionic liquids

T2 - Effect of cation rings, functional groups, and anions

AU - Kumar, R. Anand

AU - Papaïconomou, Nicolas

AU - Lee, Jong Min

AU - Salminen, Justin

AU - Clark, Douglas S.

AU - Prausnitz, John M.

PY - 2009/8

Y1 - 2009/8

N2 - In vitro cytotoxicities were measured for ionic liquids (ILs) containing various cations and anions using the MCF7 human breast cancer cell line. We measured the cytotoxicities of ionic liquids containing the cations pyridinium, pyrrolidinium, piperidinium, or imidazolium with various alkyl chain lengths, and the anions bromide, bis(trifluoromethanesulfone)imide (Tf2N), trifluoromethylsulfonate (TfO), or non-afluoromethylsulfonate (NfO). Three new hydrophobic, task-specific ionic liquids (TSILs), namely, [MBCNPip] +[Tf2N]-, [MPS2Pip] +[Tf2N]-, and [MPS2Pyrro] +[Tf2N]- designed for metal-ion extraction were also evaluated. IC50 values of the ionic liquids toward the MCF7 cells ranged from 8 μM to 44 mM. The toxicity depended significantly on the nature of the cations and anions, especially when the cations contained a long side chain. TSILs studied in this work were less toxic than the classical ILs.

AB - In vitro cytotoxicities were measured for ionic liquids (ILs) containing various cations and anions using the MCF7 human breast cancer cell line. We measured the cytotoxicities of ionic liquids containing the cations pyridinium, pyrrolidinium, piperidinium, or imidazolium with various alkyl chain lengths, and the anions bromide, bis(trifluoromethanesulfone)imide (Tf2N), trifluoromethylsulfonate (TfO), or non-afluoromethylsulfonate (NfO). Three new hydrophobic, task-specific ionic liquids (TSILs), namely, [MBCNPip] +[Tf2N]-, [MPS2Pip] +[Tf2N]-, and [MPS2Pyrro] +[Tf2N]- designed for metal-ion extraction were also evaluated. IC50 values of the ionic liquids toward the MCF7 cells ranged from 8 μM to 44 mM. The toxicity depended significantly on the nature of the cations and anions, especially when the cations contained a long side chain. TSILs studied in this work were less toxic than the classical ILs.

KW - Cytotoxicity

KW - Ionic liquids

KW - Task-specific ionic liquids

UR - http://www.scopus.com/inward/record.url?scp=67650446289&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=67650446289&partnerID=8YFLogxK

U2 - 10.1002/tox.20443

DO - 10.1002/tox.20443

M3 - Article

C2 - 18825729

AN - SCOPUS:67650446289

SN - 1520-4081

VL - 24

SP - 388

EP - 395

JO - Environmental Toxicology

JF - Environmental Toxicology

IS - 4

ER -

In vitro cytotoxicities of ionic liquids: Effect of cation rings, functional groups, and anions

Abstract

ASJC Scopus Subject Areas

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this