Indium (Zinc)-copper-mediated barbier-type alkylation reaction of nitrones in water: Synthesis of amines and hydroxylamines

Yong Sheng Yang; Zhi Liang Shen; Teck Peng Loh

doi:10.1021/ol8027362

Indium (Zinc)-copper-mediated barbier-type alkylation reaction of nitrones in water: Synthesis of amines and hydroxylamines

Yong Sheng Yang^*, Zhi Liang Shen, Teck Peng Loh

^*Corresponding author for this work

Nanyang Technological University

Research output: Contribution to journal › Article › peer-review

35 Citations (Scopus)

Abstract

An efficient method for the Barbier-type alkylation reaction of various nitrones (including chiral version) and alkyl halides in water is described. The amines and hydroxylamines can be obtained in good yields, depending on the judicious choice of the metal complexes used.

Original language	English
Pages (from-to)	1209-1212
Number of pages	4
Journal	Organic Letters
Volume	11
Issue number	6
DOIs	https://doi.org/10.1021/ol8027362
Publication status	Published - Mar 19 2009
Externally published	Yes

ASJC Scopus Subject Areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/ol8027362

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title = "Indium (Zinc)-copper-mediated barbier-type alkylation reaction of nitrones in water: Synthesis of amines and hydroxylamines",

abstract = "An efficient method for the Barbier-type alkylation reaction of various nitrones (including chiral version) and alkyl halides in water is described. The amines and hydroxylamines can be obtained in good yields, depending on the judicious choice of the metal complexes used.",

author = "Yang, \{Yong Sheng\} and Shen, \{Zhi Liang\} and Loh, \{Teck Peng\}",

year = "2009",

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doi = "10.1021/ol8027362",

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T2 - Synthesis of amines and hydroxylamines

AU - Yang, Yong Sheng

AU - Shen, Zhi Liang

AU - Loh, Teck Peng

PY - 2009/3/19

Y1 - 2009/3/19

N2 - An efficient method for the Barbier-type alkylation reaction of various nitrones (including chiral version) and alkyl halides in water is described. The amines and hydroxylamines can be obtained in good yields, depending on the judicious choice of the metal complexes used.

AB - An efficient method for the Barbier-type alkylation reaction of various nitrones (including chiral version) and alkyl halides in water is described. The amines and hydroxylamines can be obtained in good yields, depending on the judicious choice of the metal complexes used.

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Indium (Zinc)-copper-mediated barbier-type alkylation reaction of nitrones in water: Synthesis of amines and hydroxylamines

Abstract

ASJC Scopus Subject Areas

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