Indium(III) iodide-mediated Strecker reaction in water: an efficient and environmentally friendly approach for the synthesis of α-aminonitrile via a three-component condensation

Zhi Liang Shen; Shun Jun Ji; Teck Peng Loh

doi:10.1016/j.tet.2008.06.047

Indium(III) iodide-mediated Strecker reaction in water: an efficient and environmentally friendly approach for the synthesis of α-aminonitrile via a three-component condensation

Zhi Liang Shen, Shun Jun Ji^*, Teck Peng Loh

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

89 Citations (Scopus)

Abstract

A mild, efficient and environmentally friendly method has been developed for the synthesis of α-aminonitriles via a three-component condensation of aldehyde, amine and TMSCN in the presence of a catalytic amount of indium(III) iodide in water. The reactions proceeded smoothly at room temperature in water to generate the corresponding products in moderate to excellent yields.

Original language	English
Pages (from-to)	8159-8163
Number of pages	5
Journal	Tetrahedron
Volume	64
Issue number	35
DOIs	https://doi.org/10.1016/j.tet.2008.06.047
Publication status	Published - Aug 25 2008
Externally published	Yes

ASJC Scopus Subject Areas

Biochemistry
Drug Discovery
Organic Chemistry

Keywords

α-Aminonitrile
Indium(III) iodide
Strecker reaction
Three-component reaction
Water

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10.1016/j.tet.2008.06.047

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AU - Shen, Zhi Liang

AU - Ji, Shun Jun

AU - Loh, Teck Peng

PY - 2008/8/25

Y1 - 2008/8/25

N2 - A mild, efficient and environmentally friendly method has been developed for the synthesis of α-aminonitriles via a three-component condensation of aldehyde, amine and TMSCN in the presence of a catalytic amount of indium(III) iodide in water. The reactions proceeded smoothly at room temperature in water to generate the corresponding products in moderate to excellent yields.

AB - A mild, efficient and environmentally friendly method has been developed for the synthesis of α-aminonitriles via a three-component condensation of aldehyde, amine and TMSCN in the presence of a catalytic amount of indium(III) iodide in water. The reactions proceeded smoothly at room temperature in water to generate the corresponding products in moderate to excellent yields.

KW - α-Aminonitrile

KW - Indium(III) iodide

KW - Strecker reaction

KW - Three-component reaction

KW - Water

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JO - Tetrahedron

JF - Tetrahedron

IS - 35

ER -

Indium(III) iodide-mediated Strecker reaction in water: an efficient and environmentally friendly approach for the synthesis of α-aminonitrile via a three-component condensation

Abstract

ASJC Scopus Subject Areas

Keywords

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