Induction of apoptosis by hexaosmium carbonyl clusters

Kien Voon Kong; Weng Kee Leong; Lina H.K. Lim

doi:10.1016/j.jorganchem.2008.07.039

Induction of apoptosis by hexaosmium carbonyl clusters

Kien Voon Kong, Weng Kee Leong^*, Lina H.K. Lim

^*Corresponding author for this work

National University of Singapore

Research output: Contribution to journal › Article › peer-review

21 Citations (Scopus)

Abstract

A number of tri- and hexaosmium carbonyl cluster derivatives were screened for cytotoxicity against five cancer cell lines, and the hexaosmium carbonyl clusters Os₆(CO)₁₈ and Os₆(CO)₁₆(NCCH₃)₂ were found to be active against four of these, viz., ER+ breast carcinoma (MCF-7), ER-breast carcinoma (MDA-MB-231), metastatic colorectal adenocarcinoma (SW620) and hepatocarcinoma (Hepg2), with IC₅₀ values as low as 6 μM. Studies on their mode of action with the MDA-MB-231 cell line pointed to the induction of apoptosis, as has been found earlier for the trinuclear cluster Os₃(CO)₁₀(NCCH₃)₂.

Original language	English
Pages (from-to)	834-839
Number of pages	6
Journal	Journal of Organometallic Chemistry
Volume	694
Issue number	6
DOIs	https://doi.org/10.1016/j.jorganchem.2008.07.039
Publication status	Published - Mar 15 2009
Externally published	Yes

ASJC Scopus Subject Areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry
Inorganic Chemistry
Materials Chemistry

Keywords

Apoptosis
Cancer
Cluster compounds
Osmium

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.jorganchem.2008.07.039

Cite this

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title = "Induction of apoptosis by hexaosmium carbonyl clusters",

abstract = "A number of tri- and hexaosmium carbonyl cluster derivatives were screened for cytotoxicity against five cancer cell lines, and the hexaosmium carbonyl clusters Os6(CO)18 and Os6(CO)16(NCCH3)2 were found to be active against four of these, viz., ER+ breast carcinoma (MCF-7), ER-breast carcinoma (MDA-MB-231), metastatic colorectal adenocarcinoma (SW620) and hepatocarcinoma (Hepg2), with IC50 values as low as 6 μM. Studies on their mode of action with the MDA-MB-231 cell line pointed to the induction of apoptosis, as has been found earlier for the trinuclear cluster Os3(CO)10(NCCH3)2.",

keywords = "Apoptosis, Cancer, Cluster compounds, Osmium",

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doi = "10.1016/j.jorganchem.2008.07.039",

language = "English",

volume = "694",

pages = "834--839",

journal = "Journal of Organometallic Chemistry",

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T1 - Induction of apoptosis by hexaosmium carbonyl clusters

AU - Kong, Kien Voon

AU - Leong, Weng Kee

AU - Lim, Lina H.K.

PY - 2009/3/15

Y1 - 2009/3/15

N2 - A number of tri- and hexaosmium carbonyl cluster derivatives were screened for cytotoxicity against five cancer cell lines, and the hexaosmium carbonyl clusters Os6(CO)18 and Os6(CO)16(NCCH3)2 were found to be active against four of these, viz., ER+ breast carcinoma (MCF-7), ER-breast carcinoma (MDA-MB-231), metastatic colorectal adenocarcinoma (SW620) and hepatocarcinoma (Hepg2), with IC50 values as low as 6 μM. Studies on their mode of action with the MDA-MB-231 cell line pointed to the induction of apoptosis, as has been found earlier for the trinuclear cluster Os3(CO)10(NCCH3)2.

AB - A number of tri- and hexaosmium carbonyl cluster derivatives were screened for cytotoxicity against five cancer cell lines, and the hexaosmium carbonyl clusters Os6(CO)18 and Os6(CO)16(NCCH3)2 were found to be active against four of these, viz., ER+ breast carcinoma (MCF-7), ER-breast carcinoma (MDA-MB-231), metastatic colorectal adenocarcinoma (SW620) and hepatocarcinoma (Hepg2), with IC50 values as low as 6 μM. Studies on their mode of action with the MDA-MB-231 cell line pointed to the induction of apoptosis, as has been found earlier for the trinuclear cluster Os3(CO)10(NCCH3)2.

KW - Apoptosis

KW - Cancer

KW - Cluster compounds

KW - Osmium

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DO - 10.1016/j.jorganchem.2008.07.039

M3 - Article

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JO - Journal of Organometallic Chemistry

JF - Journal of Organometallic Chemistry

IS - 6

ER -

Induction of apoptosis by hexaosmium carbonyl clusters

Abstract

ASJC Scopus Subject Areas

Keywords

UN SDGs

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