Interfacing live cells with nanocarbon substrates

Shuchi Agarwal; Xiaozhu Zhou; Feng Ye; Qiyuan He; George C.K. Chen; Jianchow Soo; Freddy Boey; Hua Zhang; Peng Chen

doi:10.1021/la9048743

Interfacing live cells with nanocarbon substrates

Shuchi Agarwal, Xiaozhu Zhou, Feng Ye, Qiyuan He, George C.K. Chen, Jianchow Soo, Freddy Boey, Hua Zhang, Peng Chen^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

310 Citations (Scopus)

Abstract

Nanocarbon materials, including single-walled carbon nanotubes (SWCNTs) and graphene, promise various novel biomedical applications (e.g., nanoelectronic biosensing). In this Letter, we study the ability of SWCNT networks and reduced graphene oxide (rGO) films in interfacing several types of cells, such as neuroendocrine PC12 cells, oligodendroglia cells, and osteoblasts. It was found that rGO is biocompatible with all these cell types, whereas the SWCNT network is inhibitory to the proliferation, viability, and neuritegenesis of PC12 cells, and the proliferation of osteoblasts. These observations could be attributed to the distinct nanotopographic features of these two kinds of nanocarbon substrates.

Original language	English
Pages (from-to)	2244-2247
Number of pages	4
Journal	Langmuir
Volume	26
Issue number	4
DOIs	https://doi.org/10.1021/la9048743
Publication status	Published - Feb 16 2010
Externally published	Yes

ASJC Scopus Subject Areas

General Materials Science
Condensed Matter Physics
Surfaces and Interfaces
Spectroscopy
Electrochemistry

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10.1021/la9048743

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abstract = "Nanocarbon materials, including single-walled carbon nanotubes (SWCNTs) and graphene, promise various novel biomedical applications (e.g., nanoelectronic biosensing). In this Letter, we study the ability of SWCNT networks and reduced graphene oxide (rGO) films in interfacing several types of cells, such as neuroendocrine PC12 cells, oligodendroglia cells, and osteoblasts. It was found that rGO is biocompatible with all these cell types, whereas the SWCNT network is inhibitory to the proliferation, viability, and neuritegenesis of PC12 cells, and the proliferation of osteoblasts. These observations could be attributed to the distinct nanotopographic features of these two kinds of nanocarbon substrates.",

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T1 - Interfacing live cells with nanocarbon substrates

AU - Agarwal, Shuchi

AU - Zhou, Xiaozhu

AU - Ye, Feng

AU - He, Qiyuan

AU - Chen, George C.K.

AU - Soo, Jianchow

AU - Boey, Freddy

AU - Zhang, Hua

AU - Chen, Peng

PY - 2010/2/16

Y1 - 2010/2/16

N2 - Nanocarbon materials, including single-walled carbon nanotubes (SWCNTs) and graphene, promise various novel biomedical applications (e.g., nanoelectronic biosensing). In this Letter, we study the ability of SWCNT networks and reduced graphene oxide (rGO) films in interfacing several types of cells, such as neuroendocrine PC12 cells, oligodendroglia cells, and osteoblasts. It was found that rGO is biocompatible with all these cell types, whereas the SWCNT network is inhibitory to the proliferation, viability, and neuritegenesis of PC12 cells, and the proliferation of osteoblasts. These observations could be attributed to the distinct nanotopographic features of these two kinds of nanocarbon substrates.

AB - Nanocarbon materials, including single-walled carbon nanotubes (SWCNTs) and graphene, promise various novel biomedical applications (e.g., nanoelectronic biosensing). In this Letter, we study the ability of SWCNT networks and reduced graphene oxide (rGO) films in interfacing several types of cells, such as neuroendocrine PC12 cells, oligodendroglia cells, and osteoblasts. It was found that rGO is biocompatible with all these cell types, whereas the SWCNT network is inhibitory to the proliferation, viability, and neuritegenesis of PC12 cells, and the proliferation of osteoblasts. These observations could be attributed to the distinct nanotopographic features of these two kinds of nanocarbon substrates.

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Interfacing live cells with nanocarbon substrates

Abstract

ASJC Scopus Subject Areas

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