Interfacing peptides, identified using phage-display screening, with quantum dots for the design of nanoprobes

Sawitri Mardyani; Anupam Singhal; Wen Jiang; Warren C.W. Chan

doi:10.1117/12.601609

Interfacing peptides, identified using phage-display screening, with quantum dots for the design of nanoprobes

Sawitri Mardyani, Anupam Singhal, Wen Jiang, Warren C.W. Chan^*

^*Corresponding author for this work

University of Toronto

Research output: Contribution to journal › Conference article › peer-review

Abstract

The interface of targeting molecules that can recognize and identify specific biomolecules with highly luminescent semiconductor nanocrystals or quantum dots can lead to a novel and powerful new class of probes for studying biomolecules in real-time or for imaging and detecting diseases. We describe the rationale design of optical nanoprobes by using fluorescent semiconductor quantum dots with targeting molecules (TMs)-identified using phage display screening. Quantum dots are nanometer-sized particles with unique and tunable optical properties. They offer numerous optical advantages over traditional organic fluorophores in biological analysis and detection (e.g., photostability, continuous absorption profile).

Original language	English
Article number	49
Pages (from-to)	217-224
Number of pages	8
Journal	Progress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume	5705
DOIs	https://doi.org/10.1117/12.601609
Publication status	Published - 2005
Externally published	Yes
Event	Nanobiophotonics and Biomedical Applications II - San Jose, CA, United States Duration: Jan 24 2005 → Jan 27 2005

ASJC Scopus Subject Areas

Electronic, Optical and Magnetic Materials
Biomaterials
Atomic and Molecular Physics, and Optics
Radiology Nuclear Medicine and imaging

Keywords

Cell labeling
Nanoprobes
Optical imaging
Phage-display screening
Quantum dots
Targeting molecules

Access to Document

10.1117/12.601609

Cite this

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abstract = "The interface of targeting molecules that can recognize and identify specific biomolecules with highly luminescent semiconductor nanocrystals or quantum dots can lead to a novel and powerful new class of probes for studying biomolecules in real-time or for imaging and detecting diseases. We describe the rationale design of optical nanoprobes by using fluorescent semiconductor quantum dots with targeting molecules (TMs)-identified using phage display screening. Quantum dots are nanometer-sized particles with unique and tunable optical properties. They offer numerous optical advantages over traditional organic fluorophores in biological analysis and detection (e.g., photostability, continuous absorption profile).",

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year = "2005",

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T1 - Interfacing peptides, identified using phage-display screening, with quantum dots for the design of nanoprobes

AU - Mardyani, Sawitri

AU - Singhal, Anupam

AU - Jiang, Wen

AU - Chan, Warren C.W.

PY - 2005

Y1 - 2005

N2 - The interface of targeting molecules that can recognize and identify specific biomolecules with highly luminescent semiconductor nanocrystals or quantum dots can lead to a novel and powerful new class of probes for studying biomolecules in real-time or for imaging and detecting diseases. We describe the rationale design of optical nanoprobes by using fluorescent semiconductor quantum dots with targeting molecules (TMs)-identified using phage display screening. Quantum dots are nanometer-sized particles with unique and tunable optical properties. They offer numerous optical advantages over traditional organic fluorophores in biological analysis and detection (e.g., photostability, continuous absorption profile).

AB - The interface of targeting molecules that can recognize and identify specific biomolecules with highly luminescent semiconductor nanocrystals or quantum dots can lead to a novel and powerful new class of probes for studying biomolecules in real-time or for imaging and detecting diseases. We describe the rationale design of optical nanoprobes by using fluorescent semiconductor quantum dots with targeting molecules (TMs)-identified using phage display screening. Quantum dots are nanometer-sized particles with unique and tunable optical properties. They offer numerous optical advantages over traditional organic fluorophores in biological analysis and detection (e.g., photostability, continuous absorption profile).

KW - Cell labeling

KW - Nanoprobes

KW - Optical imaging

KW - Phage-display screening

KW - Quantum dots

KW - Targeting molecules

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JO - Progress in Biomedical Optics and Imaging - Proceedings of SPIE

JF - Progress in Biomedical Optics and Imaging - Proceedings of SPIE

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ER -

Interfacing peptides, identified using phage-display screening, with quantum dots for the design of nanoprobes

Abstract

ASJC Scopus Subject Areas

Keywords

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