Investigating the role of pparβ/δ in retinal vascular remodeling using pparβ/δ-deficient mice

Sze Yuan Ho; Yuet Ping Kwan; Beiying Qiu; Alison Tan; Hannah Louise Murray; Veluchamy Amutha Barathi; Nguan Soon Tan; Chui Ming Gemmy Cheung; Tien Yin Wong; Walter Wahli; Xiaomeng Wang

doi:10.3390/ijms21124403

Investigating the role of pparβ/δ in retinal vascular remodeling using pparβ/δ-deficient mice

Sze Yuan Ho, Yuet Ping Kwan, Beiying Qiu, Alison Tan, Hannah Louise Murray, Veluchamy Amutha Barathi, Nguan Soon Tan, Chui Ming Gemmy Cheung^*, Tien Yin Wong^*, Walter Wahli^*, Xiaomeng Wang^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

Peroxisome proliferator-activated receptor (PPAR)β/δ is a member of the nuclear receptor superfamily of transcription factors, which plays fundamental roles in cell proliferation and differentiation, inflammation, adipogenesis, and energy homeostasis. Previous studies demonstrated a reduced choroidal neovascularization (CNV) in Pparβ/δ-deficient mice. However, PPARβ/δ’s role in physiological blood vessel formation and vessel remodeling in the retina has yet to be established. Our study showed that PPARβ/δ is specifically required for disordered blood vessel formation in the retina. We further demonstrated an increased arteriovenous crossover and wider venous caliber in Pparβ/δ-haplodeficient mice. In summary, these results indicated a critical role of PPARβ/δ in pathological angiogenesis and blood vessel remodeling in the retina.

Original language	English
Article number	4403
Pages (from-to)	1-15
Number of pages	15
Journal	International Journal of Molecular Sciences
Volume	21
Issue number	12
DOIs	https://doi.org/10.3390/ijms21124403
Publication status	Published - Jun 2020
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2020 by the authors. Licensee MDPI, Basel, Switzerland.

ASJC Scopus Subject Areas

Catalysis
Molecular Biology
Spectroscopy
Computer Science Applications
Physical and Theoretical Chemistry
Organic Chemistry
Inorganic Chemistry

Keywords

Angiogenesis
Arteriovenous crossover
Blood vessel remodeling
Pericytes
PPARβ/δ
Vessel caliber

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10.3390/ijms21124403

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title = "Investigating the role of pparβ/δ in retinal vascular remodeling using pparβ/δ-deficient mice",

abstract = "Peroxisome proliferator-activated receptor (PPAR)β/δ is a member of the nuclear receptor superfamily of transcription factors, which plays fundamental roles in cell proliferation and differentiation, inflammation, adipogenesis, and energy homeostasis. Previous studies demonstrated a reduced choroidal neovascularization (CNV) in Pparβ/δ-deficient mice. However, PPARβ/δ{\textquoteright}s role in physiological blood vessel formation and vessel remodeling in the retina has yet to be established. Our study showed that PPARβ/δ is specifically required for disordered blood vessel formation in the retina. We further demonstrated an increased arteriovenous crossover and wider venous caliber in Pparβ/δ-haplodeficient mice. In summary, these results indicated a critical role of PPARβ/δ in pathological angiogenesis and blood vessel remodeling in the retina.",

keywords = "Angiogenesis, Arteriovenous crossover, Blood vessel remodeling, Pericytes, PPARβ/δ, Vessel caliber",

author = "Ho, {Sze Yuan} and Kwan, {Yuet Ping} and Beiying Qiu and Alison Tan and Murray, {Hannah Louise} and Barathi, {Veluchamy Amutha} and Tan, {Nguan Soon} and Cheung, {Chui Ming Gemmy} and Wong, {Tien Yin} and Walter Wahli and Xiaomeng Wang",

note = "Publisher Copyright: {\textcopyright} 2020 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2020",

month = jun,

doi = "10.3390/ijms21124403",

language = "English",

volume = "21",

pages = "1--15",

journal = "International Journal of Molecular Sciences",

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T1 - Investigating the role of pparβ/δ in retinal vascular remodeling using pparβ/δ-deficient mice

AU - Ho, Sze Yuan

AU - Kwan, Yuet Ping

AU - Qiu, Beiying

AU - Tan, Alison

AU - Murray, Hannah Louise

AU - Barathi, Veluchamy Amutha

AU - Tan, Nguan Soon

AU - Cheung, Chui Ming Gemmy

AU - Wong, Tien Yin

AU - Wahli, Walter

AU - Wang, Xiaomeng

PY - 2020/6

Y1 - 2020/6

N2 - Peroxisome proliferator-activated receptor (PPAR)β/δ is a member of the nuclear receptor superfamily of transcription factors, which plays fundamental roles in cell proliferation and differentiation, inflammation, adipogenesis, and energy homeostasis. Previous studies demonstrated a reduced choroidal neovascularization (CNV) in Pparβ/δ-deficient mice. However, PPARβ/δ’s role in physiological blood vessel formation and vessel remodeling in the retina has yet to be established. Our study showed that PPARβ/δ is specifically required for disordered blood vessel formation in the retina. We further demonstrated an increased arteriovenous crossover and wider venous caliber in Pparβ/δ-haplodeficient mice. In summary, these results indicated a critical role of PPARβ/δ in pathological angiogenesis and blood vessel remodeling in the retina.

AB - Peroxisome proliferator-activated receptor (PPAR)β/δ is a member of the nuclear receptor superfamily of transcription factors, which plays fundamental roles in cell proliferation and differentiation, inflammation, adipogenesis, and energy homeostasis. Previous studies demonstrated a reduced choroidal neovascularization (CNV) in Pparβ/δ-deficient mice. However, PPARβ/δ’s role in physiological blood vessel formation and vessel remodeling in the retina has yet to be established. Our study showed that PPARβ/δ is specifically required for disordered blood vessel formation in the retina. We further demonstrated an increased arteriovenous crossover and wider venous caliber in Pparβ/δ-haplodeficient mice. In summary, these results indicated a critical role of PPARβ/δ in pathological angiogenesis and blood vessel remodeling in the retina.

KW - Angiogenesis

KW - Arteriovenous crossover

KW - Blood vessel remodeling

KW - Pericytes

KW - PPARβ/δ

KW - Vessel caliber

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ER -

Investigating the role of pparβ/δ in retinal vascular remodeling using pparβ/δ-deficient mice

Abstract

Bibliographical note

ASJC Scopus Subject Areas

Keywords

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