Iron-catalyzed cascade carbochloromethylation of activated alkenes: Highly efficient access to chloro-containing oxindoles

Ming Zhu Lu; Teck Peng Loh

doi:10.1021/ol502411c

Iron-catalyzed cascade carbochloromethylation of activated alkenes: Highly efficient access to chloro-containing oxindoles

Ming Zhu Lu, Teck Peng Loh^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

137 Citations (Scopus)

Abstract

An iron-catalyzed carbodi- and trichloromethylation of activated alkenes with readily available dichloro- and tetrachloromethane has been developed. A diaryliodonium salt is used as an efficient oxidant in this transformation. This reaction tolerates a variety of functional groups and allows for a highly efficient synthesis of various chloro-containing oxindoles.

Original language	English
Pages (from-to)	4698-4701
Number of pages	4
Journal	Organic Letters
Volume	16
Issue number	18
DOIs	https://doi.org/10.1021/ol502411c
Publication status	Published - Sept 19 2014
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2014 American Chemical Society.

ASJC Scopus Subject Areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/ol502411c

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abstract = "An iron-catalyzed carbodi- and trichloromethylation of activated alkenes with readily available dichloro- and tetrachloromethane has been developed. A diaryliodonium salt is used as an efficient oxidant in this transformation. This reaction tolerates a variety of functional groups and allows for a highly efficient synthesis of various chloro-containing oxindoles.",

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AU - Loh, Teck Peng

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Y1 - 2014/9/19

N2 - An iron-catalyzed carbodi- and trichloromethylation of activated alkenes with readily available dichloro- and tetrachloromethane has been developed. A diaryliodonium salt is used as an efficient oxidant in this transformation. This reaction tolerates a variety of functional groups and allows for a highly efficient synthesis of various chloro-containing oxindoles.

AB - An iron-catalyzed carbodi- and trichloromethylation of activated alkenes with readily available dichloro- and tetrachloromethane has been developed. A diaryliodonium salt is used as an efficient oxidant in this transformation. This reaction tolerates a variety of functional groups and allows for a highly efficient synthesis of various chloro-containing oxindoles.

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Iron-catalyzed cascade carbochloromethylation of activated alkenes: Highly efficient access to chloro-containing oxindoles

Abstract

Bibliographical note

ASJC Scopus Subject Areas

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