Iron-catalyzed chemoselective cross-coupling of primary and secondary alkyl halides with arylzinc reagents

Masaharu Nakamura; Shingo Ito; Keiko Matsuo; Eiichi Nakamura

doi:10.1055/s-2005-871541

Iron-catalyzed chemoselective cross-coupling of primary and secondary alkyl halides with arylzinc reagents

Masaharu Nakamura^*, Shingo Ito, Keiko Matsuo, Eiichi Nakamura

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

146 Citations (Scopus)

Abstract

Functional-group-compatible cross-coupling reaction of alkyl halides with arylzinc reagents takes place under iron catalysis in the presence of TMEDA, producing a variety of aromatic compounds in good to excellent yield. The pronounced effect of a magnesium salt was found to be the key to the promotion of the iron-catalyzed coupling reaction.

Original language	English
Article number	Y00305ST
Pages (from-to)	1794-1798
Number of pages	5
Journal	Synlett
Issue number	11
DOIs	https://doi.org/10.1055/s-2005-871541
Publication status	Published - Jul 7 2005
Externally published	Yes

ASJC Scopus Subject Areas

Organic Chemistry

Keywords

Alkyl halides
Cross-coupling
Iron catalyst
Substitution
Zinc reagents

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abstract = "Functional-group-compatible cross-coupling reaction of alkyl halides with arylzinc reagents takes place under iron catalysis in the presence of TMEDA, producing a variety of aromatic compounds in good to excellent yield. The pronounced effect of a magnesium salt was found to be the key to the promotion of the iron-catalyzed coupling reaction.",

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author = "Masaharu Nakamura and Shingo Ito and Keiko Matsuo and Eiichi Nakamura",

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T1 - Iron-catalyzed chemoselective cross-coupling of primary and secondary alkyl halides with arylzinc reagents

AU - Nakamura, Masaharu

AU - Ito, Shingo

AU - Matsuo, Keiko

AU - Nakamura, Eiichi

PY - 2005/7/7

Y1 - 2005/7/7

N2 - Functional-group-compatible cross-coupling reaction of alkyl halides with arylzinc reagents takes place under iron catalysis in the presence of TMEDA, producing a variety of aromatic compounds in good to excellent yield. The pronounced effect of a magnesium salt was found to be the key to the promotion of the iron-catalyzed coupling reaction.

AB - Functional-group-compatible cross-coupling reaction of alkyl halides with arylzinc reagents takes place under iron catalysis in the presence of TMEDA, producing a variety of aromatic compounds in good to excellent yield. The pronounced effect of a magnesium salt was found to be the key to the promotion of the iron-catalyzed coupling reaction.

KW - Alkyl halides

KW - Cross-coupling

KW - Iron catalyst

KW - Substitution

KW - Zinc reagents

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ER -

Iron-catalyzed chemoselective cross-coupling of primary and secondary alkyl halides with arylzinc reagents

Abstract

ASJC Scopus Subject Areas

Keywords

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