Iron(0)-Mediated Reformatsky Reaction for the Synthesis of β-Hydroxyl Carbonyl Compounds

Xuan Yu Liu; Xiang Rui Li; Chen Zhang; Xue Qiang Chu; Weidong Rao; Teck Peng Loh; Zhi Liang Shen

doi:10.1021/acs.orglett.9b01999

Iron(0)-Mediated Reformatsky Reaction for the Synthesis of β-Hydroxyl Carbonyl Compounds

Xuan Yu Liu, Xiang Rui Li, Chen Zhang, Xue Qiang Chu, Weidong Rao, Teck Peng Loh^*, Zhi Liang Shen

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

21 Citations (Scopus)

Abstract

An efficient, economical, and practical Reformatsky reaction of α-halo carbonyl compounds with aldehydes/ketones by using cheap and commercial iron(0) powder as reaction mediator is developed. The reactions proceeded effectively in the presence of a catalytic amount of iodine (20 mol %) to afford the synthetically useful β-hydroxyl carbonyl compounds in moderate to good yields.

Original language	English
Pages (from-to)	5873-5878
Number of pages	6
Journal	Organic Letters
Volume	21
Issue number	15
DOIs	https://doi.org/10.1021/acs.orglett.9b01999
Publication status	Published - Aug 2 2019
Externally published	Yes

Bibliographical note

Publisher Copyright:
Copyright © 2019 American Chemical Society.

ASJC Scopus Subject Areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/acs.orglett.9b01999

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abstract = "An efficient, economical, and practical Reformatsky reaction of α-halo carbonyl compounds with aldehydes/ketones by using cheap and commercial iron(0) powder as reaction mediator is developed. The reactions proceeded effectively in the presence of a catalytic amount of iodine (20 mol %) to afford the synthetically useful β-hydroxyl carbonyl compounds in moderate to good yields.",

author = "Liu, {Xuan Yu} and Li, {Xiang Rui} and Chen Zhang and Chu, {Xue Qiang} and Weidong Rao and Loh, {Teck Peng} and Shen, {Zhi Liang}",

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AU - Liu, Xuan Yu

AU - Li, Xiang Rui

AU - Zhang, Chen

AU - Chu, Xue Qiang

AU - Rao, Weidong

AU - Loh, Teck Peng

AU - Shen, Zhi Liang

PY - 2019/8/2

Y1 - 2019/8/2

N2 - An efficient, economical, and practical Reformatsky reaction of α-halo carbonyl compounds with aldehydes/ketones by using cheap and commercial iron(0) powder as reaction mediator is developed. The reactions proceeded effectively in the presence of a catalytic amount of iodine (20 mol %) to afford the synthetically useful β-hydroxyl carbonyl compounds in moderate to good yields.

AB - An efficient, economical, and practical Reformatsky reaction of α-halo carbonyl compounds with aldehydes/ketones by using cheap and commercial iron(0) powder as reaction mediator is developed. The reactions proceeded effectively in the presence of a catalytic amount of iodine (20 mol %) to afford the synthetically useful β-hydroxyl carbonyl compounds in moderate to good yields.

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Iron(0)-Mediated Reformatsky Reaction for the Synthesis of β-Hydroxyl Carbonyl Compounds

Abstract

Bibliographical note

ASJC Scopus Subject Areas

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