ITPKB and ZNF184 are associated with Parkinson's disease risk in East Asians

Elaine Guo Yan Chew; Louis C.S. Tan; Wing Lok Au; Kumar M. Prakash; Jianjun Liu; Jia Nee Foo; Eng King Tan

doi:10.1016/j.neurobiolaging.2019.01.026

ITPKB and ZNF184 are associated with Parkinson's disease risk in East Asians

Elaine Guo Yan Chew, Louis C.S. Tan, Wing Lok Au, Kumar M. Prakash, Jianjun Liu, Jia Nee Foo^*, Eng King Tan

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

A recent meta-analysis of Parkinson's disease (PD) genome-wide association studies has identified 17 novel risk loci in the European population. We aim to assess if these reported novel risk loci are similarly implicated in PD risk within the East Asian population by analyzing the reported risk single nucleotide polymorphism or proxy single nucleotide polymorphism in 14,006 East Asian samples (779 patients and 13,227 controls). We found that 9 of the 17 reported novel PD risk loci showed very similar effects in Europeans and East Asians (I² = 0 to 10.7%), of which 2 loci ITPKB and ZNF184 were significantly associated with PD in our samples. Two of the reported risk loci, ANK2/CAMK2D and CTSB, were non-polymorphic in East Asians and therefore not implicated in PD risk in the East Asian population. Given the small effect sizes of these risk loci, further validation is needed in additional Asian samples.

Original language	English
Pages (from-to)	201.e15-201.e17
Journal	Neurobiology of Aging
Volume	86
DOIs	https://doi.org/10.1016/j.neurobiolaging.2019.01.026
Publication status	Published - Feb 2020
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2019 Elsevier Inc.

ASJC Scopus Subject Areas

General Neuroscience
Ageing
Clinical Neurology
Developmental Biology
Geriatrics and Gerontology

Keywords

Association
East Asian population
Genetics
Parkinson's disease

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10.1016/j.neurobiolaging.2019.01.026

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title = "ITPKB and ZNF184 are associated with Parkinson's disease risk in East Asians",

abstract = "A recent meta-analysis of Parkinson's disease (PD) genome-wide association studies has identified 17 novel risk loci in the European population. We aim to assess if these reported novel risk loci are similarly implicated in PD risk within the East Asian population by analyzing the reported risk single nucleotide polymorphism or proxy single nucleotide polymorphism in 14,006 East Asian samples (779 patients and 13,227 controls). We found that 9 of the 17 reported novel PD risk loci showed very similar effects in Europeans and East Asians (I2 = 0 to 10.7%), of which 2 loci ITPKB and ZNF184 were significantly associated with PD in our samples. Two of the reported risk loci, ANK2/CAMK2D and CTSB, were non-polymorphic in East Asians and therefore not implicated in PD risk in the East Asian population. Given the small effect sizes of these risk loci, further validation is needed in additional Asian samples.",

keywords = "Association, East Asian population, Genetics, Parkinson's disease",

author = "Chew, {Elaine Guo Yan} and Tan, {Louis C.S.} and Au, {Wing Lok} and Prakash, {Kumar M.} and Jianjun Liu and Foo, {Jia Nee} and Tan, {Eng King}",

note = "Publisher Copyright: {\textcopyright} 2019 Elsevier Inc.",

year = "2020",

month = feb,

doi = "10.1016/j.neurobiolaging.2019.01.026",

language = "English",

volume = "86",

pages = "201.e15--201.e17",

journal = "Neurobiology of Aging",

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TY - JOUR

T1 - ITPKB and ZNF184 are associated with Parkinson's disease risk in East Asians

AU - Chew, Elaine Guo Yan

AU - Tan, Louis C.S.

AU - Au, Wing Lok

AU - Prakash, Kumar M.

AU - Liu, Jianjun

AU - Foo, Jia Nee

AU - Tan, Eng King

PY - 2020/2

Y1 - 2020/2

N2 - A recent meta-analysis of Parkinson's disease (PD) genome-wide association studies has identified 17 novel risk loci in the European population. We aim to assess if these reported novel risk loci are similarly implicated in PD risk within the East Asian population by analyzing the reported risk single nucleotide polymorphism or proxy single nucleotide polymorphism in 14,006 East Asian samples (779 patients and 13,227 controls). We found that 9 of the 17 reported novel PD risk loci showed very similar effects in Europeans and East Asians (I2 = 0 to 10.7%), of which 2 loci ITPKB and ZNF184 were significantly associated with PD in our samples. Two of the reported risk loci, ANK2/CAMK2D and CTSB, were non-polymorphic in East Asians and therefore not implicated in PD risk in the East Asian population. Given the small effect sizes of these risk loci, further validation is needed in additional Asian samples.

AB - A recent meta-analysis of Parkinson's disease (PD) genome-wide association studies has identified 17 novel risk loci in the European population. We aim to assess if these reported novel risk loci are similarly implicated in PD risk within the East Asian population by analyzing the reported risk single nucleotide polymorphism or proxy single nucleotide polymorphism in 14,006 East Asian samples (779 patients and 13,227 controls). We found that 9 of the 17 reported novel PD risk loci showed very similar effects in Europeans and East Asians (I2 = 0 to 10.7%), of which 2 loci ITPKB and ZNF184 were significantly associated with PD in our samples. Two of the reported risk loci, ANK2/CAMK2D and CTSB, were non-polymorphic in East Asians and therefore not implicated in PD risk in the East Asian population. Given the small effect sizes of these risk loci, further validation is needed in additional Asian samples.

KW - Association

KW - East Asian population

KW - Genetics

KW - Parkinson's disease

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DO - 10.1016/j.neurobiolaging.2019.01.026

M3 - Article

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AN - SCOPUS:85061860992

SN - 0197-4580

VL - 86

SP - 201.e15-201.e17

JO - Neurobiology of Aging

JF - Neurobiology of Aging

ER -

ITPKB and ZNF184 are associated with Parkinson's disease risk in East Asians

Abstract

Bibliographical note

ASJC Scopus Subject Areas

Keywords

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