K13-Mediated Reduced Susceptibility to Artemisinin in Plasmodium falciparum Is Overlaid on a Trait of Enhanced DNA Damage Repair

Aoli Xiong; Prem Prakash; Xiaohong Gao; Marvin Chew; Ian Jun Jie Tay; Charles J. Woodrow; Bevin P. Engelward; Jongyoon Han; Peter R. Preiser

doi:10.1016/j.celrep.2020.107996

K13-Mediated Reduced Susceptibility to Artemisinin in Plasmodium falciparum Is Overlaid on a Trait of Enhanced DNA Damage Repair

Aoli Xiong, Prem Prakash, Xiaohong Gao, Marvin Chew, Ian Jun Jie Tay, Charles J. Woodrow, Bevin P. Engelward, Jongyoon Han, Peter R. Preiser^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

23 Citations (Scopus)

Abstract

Southeast Asia (SEA) has been the breeding ground for malaria drug resistance, including resistance to artemisinin, the first-line anti-malarial drug. In this study, Xiong et al. find a relationship between DNA damage repair and artemisinin resistance in SEA, leading to insights on the establishment and spread of current artemisinin resistance.

Original language	English
Article number	107996
Journal	Cell Reports
Volume	32
Issue number	5
DOIs	https://doi.org/10.1016/j.celrep.2020.107996
Publication status	Published - Aug 4 2020
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2020 The Author(s)

ASJC Scopus Subject Areas

General Biochemistry,Genetics and Molecular Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.celrep.2020.107996

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title = "K13-Mediated Reduced Susceptibility to Artemisinin in Plasmodium falciparum Is Overlaid on a Trait of Enhanced DNA Damage Repair",

abstract = "Southeast Asia (SEA) has been the breeding ground for malaria drug resistance, including resistance to artemisinin, the first-line anti-malarial drug. In this study, Xiong et al. find a relationship between DNA damage repair and artemisinin resistance in SEA, leading to insights on the establishment and spread of current artemisinin resistance.",

author = "Aoli Xiong and Prem Prakash and Xiaohong Gao and Marvin Chew and Tay, {Ian Jun Jie} and Woodrow, {Charles J.} and Engelward, {Bevin P.} and Jongyoon Han and Preiser, {Peter R.}",

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doi = "10.1016/j.celrep.2020.107996",

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AU - Xiong, Aoli

AU - Prakash, Prem

AU - Gao, Xiaohong

AU - Chew, Marvin

AU - Tay, Ian Jun Jie

AU - Woodrow, Charles J.

AU - Engelward, Bevin P.

AU - Han, Jongyoon

AU - Preiser, Peter R.

PY - 2020/8/4

Y1 - 2020/8/4

N2 - Southeast Asia (SEA) has been the breeding ground for malaria drug resistance, including resistance to artemisinin, the first-line anti-malarial drug. In this study, Xiong et al. find a relationship between DNA damage repair and artemisinin resistance in SEA, leading to insights on the establishment and spread of current artemisinin resistance.

AB - Southeast Asia (SEA) has been the breeding ground for malaria drug resistance, including resistance to artemisinin, the first-line anti-malarial drug. In this study, Xiong et al. find a relationship between DNA damage repair and artemisinin resistance in SEA, leading to insights on the establishment and spread of current artemisinin resistance.

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JF - Cell Reports

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K13-Mediated Reduced Susceptibility to Artemisinin in Plasmodium falciparum Is Overlaid on a Trait of Enhanced DNA Damage Repair

Abstract

Bibliographical note

ASJC Scopus Subject Areas

UN SDGs

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