Linking hydrophilic macromolecules to monodisperse magnetite (Fe 3O 4) nanoparticles via trichloro-s-triazine

Jin Xie; Chenjie Xu; Zhichuan Xu; Yanglong Hou; Kaylie L. Young; S. X. Wang; N. Pourmond; Shouheng Sun

doi:10.1021/cm061793c

Linking hydrophilic macromolecules to monodisperse magnetite (Fe ₃O ₄) nanoparticles via trichloro-s-triazine

Jin Xie, Chenjie Xu, Zhichuan Xu, Yanglong Hou, Kaylie L. Young, S. X. Wang, N. Pourmond, Shouheng Sun^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

194 Citations (Scopus)

Abstract

A simple approach to conjugate monodisperse Fe ₃O ₄ nanoparticles with various poly(ethylene glycol) (PEG)-based hydrophillic macromolecules through a readily available linker trichloro-s-triazine (TsT) was investigated. Fe ₃O ₄ nanoparticles have been tested vigorously for various biomedical applications because of their chemical stability and low toxicity. The monodisperse Fe ₃O ₄ nanoparticles were prepared by one-pot high temperature reductive decomposition of Fe(acac) ₃ in oleylamine and benzyl ether. To functionalize the Fe ₃O ₄ nanoparticles with mPEG TsT was first used to react with mPEG 2000 at room temperature in anhydrous benzene. It was observed that TsT can be used as an easy linker to couple magnetic Fe ₃O ₄ nanoparticles with hydrophilic mPEG and TsT-based linking strategy can be extended to the coupling of various hydrophilic macromolecules.

Original language	English
Pages (from-to)	5401-5403
Number of pages	3
Journal	Chemistry of Materials
Volume	18
Issue number	23
DOIs	https://doi.org/10.1021/cm061793c
Publication status	Published - Nov 14 2006
Externally published	Yes

ASJC Scopus Subject Areas

General Chemistry
General Chemical Engineering
Materials Chemistry

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10.1021/cm061793c

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title = "Linking hydrophilic macromolecules to monodisperse magnetite (Fe 3O 4) nanoparticles via trichloro-s-triazine",

abstract = "A simple approach to conjugate monodisperse Fe 3O 4 nanoparticles with various poly(ethylene glycol) (PEG)-based hydrophillic macromolecules through a readily available linker trichloro-s-triazine (TsT) was investigated. Fe 3O 4 nanoparticles have been tested vigorously for various biomedical applications because of their chemical stability and low toxicity. The monodisperse Fe 3O 4 nanoparticles were prepared by one-pot high temperature reductive decomposition of Fe(acac) 3 in oleylamine and benzyl ether. To functionalize the Fe 3O 4 nanoparticles with mPEG TsT was first used to react with mPEG 2000 at room temperature in anhydrous benzene. It was observed that TsT can be used as an easy linker to couple magnetic Fe 3O 4 nanoparticles with hydrophilic mPEG and TsT-based linking strategy can be extended to the coupling of various hydrophilic macromolecules.",

author = "Jin Xie and Chenjie Xu and Zhichuan Xu and Yanglong Hou and Young, {Kaylie L.} and Wang, {S. X.} and N. Pourmond and Shouheng Sun",

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T1 - Linking hydrophilic macromolecules to monodisperse magnetite (Fe 3O 4) nanoparticles via trichloro-s-triazine

AU - Xie, Jin

AU - Xu, Chenjie

AU - Xu, Zhichuan

AU - Hou, Yanglong

AU - Young, Kaylie L.

AU - Wang, S. X.

AU - Pourmond, N.

AU - Sun, Shouheng

PY - 2006/11/14

Y1 - 2006/11/14

N2 - A simple approach to conjugate monodisperse Fe 3O 4 nanoparticles with various poly(ethylene glycol) (PEG)-based hydrophillic macromolecules through a readily available linker trichloro-s-triazine (TsT) was investigated. Fe 3O 4 nanoparticles have been tested vigorously for various biomedical applications because of their chemical stability and low toxicity. The monodisperse Fe 3O 4 nanoparticles were prepared by one-pot high temperature reductive decomposition of Fe(acac) 3 in oleylamine and benzyl ether. To functionalize the Fe 3O 4 nanoparticles with mPEG TsT was first used to react with mPEG 2000 at room temperature in anhydrous benzene. It was observed that TsT can be used as an easy linker to couple magnetic Fe 3O 4 nanoparticles with hydrophilic mPEG and TsT-based linking strategy can be extended to the coupling of various hydrophilic macromolecules.

AB - A simple approach to conjugate monodisperse Fe 3O 4 nanoparticles with various poly(ethylene glycol) (PEG)-based hydrophillic macromolecules through a readily available linker trichloro-s-triazine (TsT) was investigated. Fe 3O 4 nanoparticles have been tested vigorously for various biomedical applications because of their chemical stability and low toxicity. The monodisperse Fe 3O 4 nanoparticles were prepared by one-pot high temperature reductive decomposition of Fe(acac) 3 in oleylamine and benzyl ether. To functionalize the Fe 3O 4 nanoparticles with mPEG TsT was first used to react with mPEG 2000 at room temperature in anhydrous benzene. It was observed that TsT can be used as an easy linker to couple magnetic Fe 3O 4 nanoparticles with hydrophilic mPEG and TsT-based linking strategy can be extended to the coupling of various hydrophilic macromolecules.

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Linking hydrophilic macromolecules to monodisperse magnetite (Fe ₃O ₄) nanoparticles via trichloro-s-triazine

Abstract

ASJC Scopus Subject Areas

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