Long-term omeprazole therapy does not affect helicobacter pylori status in most patients

E. J. Kuipers; E. C. Klinkenberg-Knol; H. P.M. Festen; C. B.H.W. Lamers; J. B.M.J. Jansen; P. Snel; F. Nelis; S. G.M. Meuwissen

doi:10.3109/00365529309098295

Long-term omeprazole therapy does not affect helicobacter pylori status in most patients

E. J. Kuipers^*, E. C. Klinkenberg-Knol, H. P.M. Festen, C. B.H.W. Lamers, J. B.M.J. Jansen, P. Snel, F. Nelis, S. G.M. Meuwissen

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

22 Citations (Scopus)

Abstract

Fifty-one patients were treated with 20-60 mg omeprazole for reflux oesophagitis resistant to H₂-blocker therapy during a mean of 49 months of follow-up. With use of a standardized enzyme-linked immunosorbent assay technique specific IgG and IgG Helicobacter pylori antibodies were determined in serum obtained at the start of therapy and at the most recent visit. At the start of therapy 26 patients (51% had evidence of H. pylori infection, as demonstrated by increased IgG and IgA antibody levels. During follow-up, 4 of these 26 patients (15% became H. pylori seronegative. It is concluded that long-term treatment with omeprazole has no effect on H. pylori status in most patients.

Original language	English
Pages (from-to)	978-980
Number of pages	3
Journal	Scandinavian Journal of Gastroenterology
Volume	28
Issue number	11
DOIs	https://doi.org/10.3109/00365529309098295
Publication status	Published - 1993
Externally published	Yes

ASJC Scopus Subject Areas

Gastroenterology

Keywords

Helicobacter pylori
Long-term treatment
Omeprazole
Serology
Serum antibodies

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title = "Long-term omeprazole therapy does not affect helicobacter pylori status in most patients",

abstract = "Fifty-one patients were treated with 20-60 mg omeprazole for reflux oesophagitis resistant to H2-blocker therapy during a mean of 49 months of follow-up. With use of a standardized enzyme-linked immunosorbent assay technique specific IgG and IgG Helicobacter pylori antibodies were determined in serum obtained at the start of therapy and at the most recent visit. At the start of therapy 26 patients (51% had evidence of H. pylori infection, as demonstrated by increased IgG and IgA antibody levels. During follow-up, 4 of these 26 patients (15% became H. pylori seronegative. It is concluded that long-term treatment with omeprazole has no effect on H. pylori status in most patients.",

keywords = "Helicobacter pylori, Long-term treatment, Omeprazole, Serology, Serum antibodies",

author = "Kuipers, {E. J.} and Klinkenberg-Knol, {E. C.} and Festen, {H. P.M.} and Lamers, {C. B.H.W.} and Jansen, {J. B.M.J.} and P. Snel and F. Nelis and Meuwissen, {S. G.M.}",

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T1 - Long-term omeprazole therapy does not affect helicobacter pylori status in most patients

AU - Kuipers, E. J.

AU - Klinkenberg-Knol, E. C.

AU - Festen, H. P.M.

AU - Lamers, C. B.H.W.

AU - Jansen, J. B.M.J.

AU - Snel, P.

AU - Nelis, F.

AU - Meuwissen, S. G.M.

PY - 1993

Y1 - 1993

N2 - Fifty-one patients were treated with 20-60 mg omeprazole for reflux oesophagitis resistant to H2-blocker therapy during a mean of 49 months of follow-up. With use of a standardized enzyme-linked immunosorbent assay technique specific IgG and IgG Helicobacter pylori antibodies were determined in serum obtained at the start of therapy and at the most recent visit. At the start of therapy 26 patients (51% had evidence of H. pylori infection, as demonstrated by increased IgG and IgA antibody levels. During follow-up, 4 of these 26 patients (15% became H. pylori seronegative. It is concluded that long-term treatment with omeprazole has no effect on H. pylori status in most patients.

AB - Fifty-one patients were treated with 20-60 mg omeprazole for reflux oesophagitis resistant to H2-blocker therapy during a mean of 49 months of follow-up. With use of a standardized enzyme-linked immunosorbent assay technique specific IgG and IgG Helicobacter pylori antibodies were determined in serum obtained at the start of therapy and at the most recent visit. At the start of therapy 26 patients (51% had evidence of H. pylori infection, as demonstrated by increased IgG and IgA antibody levels. During follow-up, 4 of these 26 patients (15% became H. pylori seronegative. It is concluded that long-term treatment with omeprazole has no effect on H. pylori status in most patients.

KW - Helicobacter pylori

KW - Long-term treatment

KW - Omeprazole

KW - Serology

KW - Serum antibodies

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Long-term omeprazole therapy does not affect helicobacter pylori status in most patients

Abstract

ASJC Scopus Subject Areas

Keywords

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