Magnetic PNIPA hydrogels for hyperthermia applications in cancer therapy

K. L. Ang; S. Venkatraman; R. V. Ramanujan

doi:10.1016/j.msec.2006.05.027

Magnetic PNIPA hydrogels for hyperthermia applications in cancer therapy

K. L. Ang, S. Venkatraman, R. V. Ramanujan^*

^*Corresponding author for this work

Nanyang Technological University

Research output: Contribution to journal › Article › peer-review

95 Citations (Scopus)

Abstract

Temperature-sensitive Poly (N-isopropylacrylamide), PNIPA gels were synthesized with micron-sized iron and iron oxide (Fe₃O₄) particles to investigate their viability for combined hyperthermia and drug release applications. The ultimate goal is to combine hyperthermia and triggered drug release. Induction heating of the magnetic hydrogels with varying concentration of magnetic powder was conducted at a frequency of 375 kHz for magnetic field strength varying from 1.7 kA/m to 2.5 kA/m. It was observed that the maximum temperature induced in the magnetic hydrogels increased with the concentration of magnetic particles and magnetic field strength. The PNIPA gel underwent a collapse transition at 34 °C. The best combination was found for the PNIPA-Fe₃O₄ system, 2.5 wt.% Fe₃O₄ in PNIPA-Fe₃O₄ system took 260 s to be heated to 45 °C under a magnetic field strength of 1.7 kA/m and the specific absorption rate (SAR) was found to be 1.83. SAR of iron oxide was found to be higher than the SAR of iron.

Original language	English
Pages (from-to)	347-351
Number of pages	5
Journal	Materials Science and Engineering C
Volume	27
Issue number	3
DOIs	https://doi.org/10.1016/j.msec.2006.05.027
Publication status	Published - Apr 2007
Externally published	Yes

ASJC Scopus Subject Areas

General Materials Science
Condensed Matter Physics
Mechanics of Materials
Mechanical Engineering

Keywords

Cancer therapy
Hyperthermia
Iron
Iron oxide
PNIPA

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.msec.2006.05.027

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title = "Magnetic PNIPA hydrogels for hyperthermia applications in cancer therapy",

abstract = "Temperature-sensitive Poly (N-isopropylacrylamide), PNIPA gels were synthesized with micron-sized iron and iron oxide (Fe3O4) particles to investigate their viability for combined hyperthermia and drug release applications. The ultimate goal is to combine hyperthermia and triggered drug release. Induction heating of the magnetic hydrogels with varying concentration of magnetic powder was conducted at a frequency of 375 kHz for magnetic field strength varying from 1.7 kA/m to 2.5 kA/m. It was observed that the maximum temperature induced in the magnetic hydrogels increased with the concentration of magnetic particles and magnetic field strength. The PNIPA gel underwent a collapse transition at 34 °C. The best combination was found for the PNIPA-Fe3O4 system, 2.5 wt.\% Fe3O4 in PNIPA-Fe3O4 system took 260 s to be heated to 45 °C under a magnetic field strength of 1.7 kA/m and the specific absorption rate (SAR) was found to be 1.83. SAR of iron oxide was found to be higher than the SAR of iron.",

keywords = "Cancer therapy, Hyperthermia, Iron, Iron oxide, PNIPA",

author = "Ang, \{K. L.\} and S. Venkatraman and Ramanujan, \{R. V.\}",

year = "2007",

month = apr,

doi = "10.1016/j.msec.2006.05.027",

language = "English",

volume = "27",

pages = "347--351",

journal = "Materials Science and Engineering C",

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TY - JOUR

T1 - Magnetic PNIPA hydrogels for hyperthermia applications in cancer therapy

AU - Ang, K. L.

AU - Venkatraman, S.

AU - Ramanujan, R. V.

PY - 2007/4

Y1 - 2007/4

N2 - Temperature-sensitive Poly (N-isopropylacrylamide), PNIPA gels were synthesized with micron-sized iron and iron oxide (Fe3O4) particles to investigate their viability for combined hyperthermia and drug release applications. The ultimate goal is to combine hyperthermia and triggered drug release. Induction heating of the magnetic hydrogels with varying concentration of magnetic powder was conducted at a frequency of 375 kHz for magnetic field strength varying from 1.7 kA/m to 2.5 kA/m. It was observed that the maximum temperature induced in the magnetic hydrogels increased with the concentration of magnetic particles and magnetic field strength. The PNIPA gel underwent a collapse transition at 34 °C. The best combination was found for the PNIPA-Fe3O4 system, 2.5 wt.% Fe3O4 in PNIPA-Fe3O4 system took 260 s to be heated to 45 °C under a magnetic field strength of 1.7 kA/m and the specific absorption rate (SAR) was found to be 1.83. SAR of iron oxide was found to be higher than the SAR of iron.

AB - Temperature-sensitive Poly (N-isopropylacrylamide), PNIPA gels were synthesized with micron-sized iron and iron oxide (Fe3O4) particles to investigate their viability for combined hyperthermia and drug release applications. The ultimate goal is to combine hyperthermia and triggered drug release. Induction heating of the magnetic hydrogels with varying concentration of magnetic powder was conducted at a frequency of 375 kHz for magnetic field strength varying from 1.7 kA/m to 2.5 kA/m. It was observed that the maximum temperature induced in the magnetic hydrogels increased with the concentration of magnetic particles and magnetic field strength. The PNIPA gel underwent a collapse transition at 34 °C. The best combination was found for the PNIPA-Fe3O4 system, 2.5 wt.% Fe3O4 in PNIPA-Fe3O4 system took 260 s to be heated to 45 °C under a magnetic field strength of 1.7 kA/m and the specific absorption rate (SAR) was found to be 1.83. SAR of iron oxide was found to be higher than the SAR of iron.

KW - Cancer therapy

KW - Hyperthermia

KW - Iron

KW - Iron oxide

KW - PNIPA

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DO - 10.1016/j.msec.2006.05.027

M3 - Article

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SN - 0928-4931

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EP - 351

JO - Materials Science and Engineering C

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IS - 3

ER -

Magnetic PNIPA hydrogels for hyperthermia applications in cancer therapy

Abstract

ASJC Scopus Subject Areas

Keywords

UN SDGs

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