Manipulating magnetic 3D spheroids in hanging drops for applications in tissue engineering and drug screening

Vincent H.B. Ho; Wei Mei Guo; Charlotte L. Huang; Shu Fen Ho; Su Yin Chaw; Ern Yu Tan; Kee Woei Ng; Joachim S.C. Loo

doi:10.1002/adhm.201200408

Manipulating magnetic 3D spheroids in hanging drops for applications in tissue engineering and drug screening

Vincent H.B. Ho^*, Wei Mei Guo, Charlotte L. Huang, Shu Fen Ho, Su Yin Chaw, Ern Yu Tan, Kee Woei Ng, Joachim S.C. Loo

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

35 Citations (Scopus)

Abstract

Magnetic spheroid manipulation can be carried out in hanging drops to generate distinctly structured heterotypic microtissues through sequential addition of cells or spheroid to homotypic spheroids. These spheroids can also be incorporated in a droplet-based assay to screen for therapeutic efficacy in prolonged studies. This simple and versatile technique can offer potential benefits in tissue engineering and drug screening applications.

Original language	English
Pages (from-to)	1430-1434
Number of pages	5
Journal	Advanced healthcare materials
Volume	2
Issue number	11
DOIs	https://doi.org/10.1002/adhm.201200408
Publication status	Published - Nov 2013
Externally published	Yes

ASJC Scopus Subject Areas

Biomaterials
Biomedical Engineering
Pharmaceutical Science

Keywords

Drug screening
Magnetic separation
Multicellular spheroids
Nanoparticles
Tissue engineering

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10.1002/adhm.201200408

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abstract = "Magnetic spheroid manipulation can be carried out in hanging drops to generate distinctly structured heterotypic microtissues through sequential addition of cells or spheroid to homotypic spheroids. These spheroids can also be incorporated in a droplet-based assay to screen for therapeutic efficacy in prolonged studies. This simple and versatile technique can offer potential benefits in tissue engineering and drug screening applications.",

keywords = "Drug screening, Magnetic separation, Multicellular spheroids, Nanoparticles, Tissue engineering",

author = "Ho, {Vincent H.B.} and Guo, {Wei Mei} and Huang, {Charlotte L.} and Ho, {Shu Fen} and Chaw, {Su Yin} and Tan, {Ern Yu} and Ng, {Kee Woei} and Loo, {Joachim S.C.}",

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AU - Ho, Vincent H.B.

AU - Guo, Wei Mei

AU - Huang, Charlotte L.

AU - Ho, Shu Fen

AU - Chaw, Su Yin

AU - Tan, Ern Yu

AU - Ng, Kee Woei

AU - Loo, Joachim S.C.

PY - 2013/11

Y1 - 2013/11

N2 - Magnetic spheroid manipulation can be carried out in hanging drops to generate distinctly structured heterotypic microtissues through sequential addition of cells or spheroid to homotypic spheroids. These spheroids can also be incorporated in a droplet-based assay to screen for therapeutic efficacy in prolonged studies. This simple and versatile technique can offer potential benefits in tissue engineering and drug screening applications.

AB - Magnetic spheroid manipulation can be carried out in hanging drops to generate distinctly structured heterotypic microtissues through sequential addition of cells or spheroid to homotypic spheroids. These spheroids can also be incorporated in a droplet-based assay to screen for therapeutic efficacy in prolonged studies. This simple and versatile technique can offer potential benefits in tissue engineering and drug screening applications.

KW - Drug screening

KW - Magnetic separation

KW - Multicellular spheroids

KW - Nanoparticles

KW - Tissue engineering

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JO - Advanced healthcare materials

JF - Advanced healthcare materials

IS - 11

ER -

Manipulating magnetic 3D spheroids in hanging drops for applications in tissue engineering and drug screening

Abstract

ASJC Scopus Subject Areas

Keywords

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