Micro-optical coherence tomography tracking of magnetic gene transfection via Au-Fe3O4 dumbbell nanoparticles

Wei Shi; Xinyu Liu; Chao Wei; Zhichuan J. Xu; Stanley Siong Wei Sim; Linbo Liu; Chenjie Xu

doi:10.1039/c5nr05459a

Micro-optical coherence tomography tracking of magnetic gene transfection via Au-Fe₃O₄ dumbbell nanoparticles

Wei Shi, Xinyu Liu, Chao Wei, Zhichuan J. Xu, Stanley Siong Wei Sim, Linbo Liu^*, Chenjie Xu

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

21 Citations (Scopus)

Abstract

Heterogeneous Au-Fe₃O₄ dumbbell nanoparticles (NPs) are composed of Au NPs and Fe₃O₄ NPs that bring in optical and magnetic properties respectively. This article reports the engineering of Au-Fe₃O₄ NPs as gene carriers for magnetic gene transfection as well as contrast agents for micro-optical coherence tomography (μOCT). As a proof-of-concept, Au-Fe₃O₄ NPs are used to deliver the green fluorescent protein to HEK 293T cells and their entrance into the cells is monitored through μOCT.

Original language	English
Pages (from-to)	17249-17253
Number of pages	5
Journal	Nanoscale
Volume	7
Issue number	41
DOIs	https://doi.org/10.1039/c5nr05459a
Publication status	Published - Nov 7 2015
Externally published	Yes

Bibliographical note

Publisher Copyright:
© The Royal Society of Chemistry 2015.

ASJC Scopus Subject Areas

General Materials Science

Access to Document

10.1039/c5nr05459a

Cite this

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abstract = "Heterogeneous Au-Fe3O4 dumbbell nanoparticles (NPs) are composed of Au NPs and Fe3O4 NPs that bring in optical and magnetic properties respectively. This article reports the engineering of Au-Fe3O4 NPs as gene carriers for magnetic gene transfection as well as contrast agents for micro-optical coherence tomography (μOCT). As a proof-of-concept, Au-Fe3O4 NPs are used to deliver the green fluorescent protein to HEK 293T cells and their entrance into the cells is monitored through μOCT.",

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