Modular amino acids-based chiral ligands for copper-catalyzed enantioselective conjugation addition of diethylzinc to cyclic enones

Shaohua Gou; Zaher M.A. Judeh

doi:10.1002/chir.20881

Modular amino acids-based chiral ligands for copper-catalyzed enantioselective conjugation addition of diethylzinc to cyclic enones

Shaohua Gou, Zaher M.A. Judeh

Nanyang Technological University

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

New amino acid-based modular chiral ligands were readily synthesized and used to catalyze the asymmetric conjugate addition of Et₂Zn to various cyclic enones in the presence of a variety of copper sources. Moderately high ee of up to 72% were obtained using ligand (S)-1e under mild conditions.

Original language	English
Pages (from-to)	105-112
Number of pages	8
Journal	Chirality
Volume	23
Issue number	2
DOIs	https://doi.org/10.1002/chir.20881
Publication status	Published - Feb 2011
Externally published	Yes

ASJC Scopus Subject Areas

Catalysis
Analytical Chemistry
Pharmacology
Drug Discovery
Spectroscopy
Organic Chemistry

Keywords

alkylation
amino acids
conjugate addition
diethylzinc
enones

Access to Document

10.1002/chir.20881

Cite this

@article{e6da064c2bee4ccfba25b9629c78e311,

title = "Modular amino acids-based chiral ligands for copper-catalyzed enantioselective conjugation addition of diethylzinc to cyclic enones",

abstract = "New amino acid-based modular chiral ligands were readily synthesized and used to catalyze the asymmetric conjugate addition of Et2Zn to various cyclic enones in the presence of a variety of copper sources. Moderately high ee of up to 72% were obtained using ligand (S)-1e under mild conditions.",

keywords = "alkylation, amino acids, conjugate addition, diethylzinc, enones",

author = "Shaohua Gou and Judeh, {Zaher M.A.}",

year = "2011",

month = feb,

doi = "10.1002/chir.20881",

language = "English",

volume = "23",

pages = "105--112",

journal = "Chirality",

issn = "0899-0042",

publisher = "Wiley-Liss Inc.",

number = "2",

}

TY - JOUR

T1 - Modular amino acids-based chiral ligands for copper-catalyzed enantioselective conjugation addition of diethylzinc to cyclic enones

AU - Gou, Shaohua

AU - Judeh, Zaher M.A.

PY - 2011/2

Y1 - 2011/2

N2 - New amino acid-based modular chiral ligands were readily synthesized and used to catalyze the asymmetric conjugate addition of Et2Zn to various cyclic enones in the presence of a variety of copper sources. Moderately high ee of up to 72% were obtained using ligand (S)-1e under mild conditions.

AB - New amino acid-based modular chiral ligands were readily synthesized and used to catalyze the asymmetric conjugate addition of Et2Zn to various cyclic enones in the presence of a variety of copper sources. Moderately high ee of up to 72% were obtained using ligand (S)-1e under mild conditions.

KW - alkylation

KW - amino acids

KW - conjugate addition

KW - diethylzinc

KW - enones

UR - http://www.scopus.com/inward/record.url?scp=78650935762&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=78650935762&partnerID=8YFLogxK

U2 - 10.1002/chir.20881

DO - 10.1002/chir.20881

M3 - Article

C2 - 20549777

AN - SCOPUS:78650935762

SN - 0899-0042

VL - 23

SP - 105

EP - 112

JO - Chirality

JF - Chirality

IS - 2

ER -

Modular amino acids-based chiral ligands for copper-catalyzed enantioselective conjugation addition of diethylzinc to cyclic enones

Abstract

ASJC Scopus Subject Areas

Keywords

Access to Document

Other files and links

Fingerprint

Cite this