Modulating Antimicrobial Activity and Mammalian Cell Biocompatibility with Glucosamine-Functionalized Star Polymers

Edgar H.H. Wong; Mya Mya Khin; Vikashini Ravikumar; Zhangyong Si; Scott A. Rice; Mary B. Chan-Park

doi:10.1021/acs.biomac.5b01766

Modulating Antimicrobial Activity and Mammalian Cell Biocompatibility with Glucosamine-Functionalized Star Polymers

Edgar H.H. Wong^*, Mya Mya Khin, Vikashini Ravikumar, Zhangyong Si, Scott A. Rice, Mary B. Chan-Park

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

86 Citations (Scopus)

Abstract

The development of novel reagents and antibiotics for combating multidrug resistance bacteria has received significant attention in recent years. In this study, new antimicrobial star polymers (14-26 nm in diameter) that consist of mixtures of polylysine and glycopolymer arms were developed and were shown to possess antimicrobial efficacy toward Gram positive bacteria including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus (VRE) (with MIC values as low as 16 μ mL^-1) while being non-hemolytic (HC₅₀ > 10 000 μ mL^-1) and exhibit excellent mammalian cell biocompatibility. Structure function analysis indicated that the antimicrobial activity and mammalian cell biocompatibility of the star nanoparticles could be optimized by modifying the molar ratio of polylysine to glycopolymers arms. The technology described herein thus represents an innovative approach that could be used to fight deadly infectious diseases.

Original language	English
Pages (from-to)	1170-1178
Number of pages	9
Journal	Biomacromolecules
Volume	17
Issue number	3
DOIs	https://doi.org/10.1021/acs.biomac.5b01766
Publication status	Published - Mar 14 2016
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2016 American Chemical Society.

ASJC Scopus Subject Areas

Bioengineering
Biomaterials
Polymers and Plastics
Materials Chemistry

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1021/acs.biomac.5b01766

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abstract = "The development of novel reagents and antibiotics for combating multidrug resistance bacteria has received significant attention in recent years. In this study, new antimicrobial star polymers (14-26 nm in diameter) that consist of mixtures of polylysine and glycopolymer arms were developed and were shown to possess antimicrobial efficacy toward Gram positive bacteria including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus (VRE) (with MIC values as low as 16 μ mL-1) while being non-hemolytic (HC50 > 10 000 μ mL-1) and exhibit excellent mammalian cell biocompatibility. Structure function analysis indicated that the antimicrobial activity and mammalian cell biocompatibility of the star nanoparticles could be optimized by modifying the molar ratio of polylysine to glycopolymers arms. The technology described herein thus represents an innovative approach that could be used to fight deadly infectious diseases.",

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AU - Si, Zhangyong

AU - Rice, Scott A.

AU - Chan-Park, Mary B.

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Modulating Antimicrobial Activity and Mammalian Cell Biocompatibility with Glucosamine-Functionalized Star Polymers

Abstract

Bibliographical note

ASJC Scopus Subject Areas

UN SDGs

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