Abstract
The neuroinflammatory response that is elicited after spinal cord injury contributes to both tissue damage and reparative processes. The complex and dynamic cellular and molecular changes within the spinal cord microenvironment result in a functional imbalance of immune cells and their modulatory factors. To facilitate wound healing and repair, it is necessary to manipulate the immunological pathways during neuroinflammation to achieve successful therapeutic interventions. In this review, recent advancements and fresh perspectives on the consequences of neuroinflammation after SCI and modulation of the inflammatory responses through the use of molecular-, cellular-, and biomaterial-based therapies to promote tissue regeneration and functional recovery will be discussed.
| Original language | English |
|---|---|
| Article number | e10389 |
| Journal | Bioengineering and Translational Medicine |
| Volume | 8 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Mar 2023 |
| Externally published | Yes |
Bibliographical note
Publisher Copyright:© 2022 The Authors. Bioengineering & Translational Medicine published by Wiley Periodicals LLC on behalf of American Institute of Chemical Engineers.
ASJC Scopus Subject Areas
- Biotechnology
- Biomedical Engineering
- Pharmaceutical Science
Keywords
- central nervous system
- inflammatory response
- nerve regeneration
- neural tissue engineering
- tissue engineering scaffolds