Molecular connections between circadian rhythm and genome maintenance pathways

Arun Mouli Kolinjivadi; Siao Ting Chong; Joanne Ngeow

doi:10.1530/ERC-20-0390

Molecular connections between circadian rhythm and genome maintenance pathways

Arun Mouli Kolinjivadi, Siao Ting Chong, Joanne Ngeow^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

15 Citations (Scopus)

Abstract

Co-ordinated oscillation of mammalian circadian clock and cell cycle is essential for cellular and organismal homeostasis. Existing preclinical, epidemiological, molecular and biochemical evidence reveals a robust interplay between circadian clock, genome instability and cancer. Furthermore, recent investigations have demonstrated that the alterations in circadian clock perturb genome stability by modulating the cell-cycle timing, altering DNA replication fork progression, influencing DNA damage response (DDR) and DNA repair efficiency. In this review, we examine the most recent findings from different eukaryotic model systems and discuss the functional interaction between circadian factors with key DNA replication, DDR and DNA repair genes.

Original language	English
Pages (from-to)	R55-R66
Journal	Endocrine-Related Cancer
Volume	28
Issue number	2
DOIs	https://doi.org/10.1530/ERC-20-0390
Publication status	Published - Feb 2021
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2021 Society for Endocrinology Published by Bioscientifica Ltd. Printed in Great Britain

ASJC Scopus Subject Areas

Endocrinology, Diabetes and Metabolism
Oncology
Endocrinology
Cancer Research

Keywords

ATM
ATR
Chronotherapy
Circadian clock
DNA damage response (DDR)
DNA repair
DNA replication
Genome instability
PARP1

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1530/ERC-20-0390

Cite this

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abstract = "Co-ordinated oscillation of mammalian circadian clock and cell cycle is essential for cellular and organismal homeostasis. Existing preclinical, epidemiological, molecular and biochemical evidence reveals a robust interplay between circadian clock, genome instability and cancer. Furthermore, recent investigations have demonstrated that the alterations in circadian clock perturb genome stability by modulating the cell-cycle timing, altering DNA replication fork progression, influencing DNA damage response (DDR) and DNA repair efficiency. In this review, we examine the most recent findings from different eukaryotic model systems and discuss the functional interaction between circadian factors with key DNA replication, DDR and DNA repair genes.",

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AU - Kolinjivadi, Arun Mouli

AU - Chong, Siao Ting

AU - Ngeow, Joanne

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AB - Co-ordinated oscillation of mammalian circadian clock and cell cycle is essential for cellular and organismal homeostasis. Existing preclinical, epidemiological, molecular and biochemical evidence reveals a robust interplay between circadian clock, genome instability and cancer. Furthermore, recent investigations have demonstrated that the alterations in circadian clock perturb genome stability by modulating the cell-cycle timing, altering DNA replication fork progression, influencing DNA damage response (DDR) and DNA repair efficiency. In this review, we examine the most recent findings from different eukaryotic model systems and discuss the functional interaction between circadian factors with key DNA replication, DDR and DNA repair genes.

KW - ATM

KW - ATR

KW - Chronotherapy

KW - Circadian clock

KW - DNA damage response (DDR)

KW - DNA repair

KW - DNA replication

KW - Genome instability

KW - PARP1

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Molecular connections between circadian rhythm and genome maintenance pathways

Abstract

Bibliographical note

ASJC Scopus Subject Areas

Keywords

UN SDGs

Access to Document

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