Multi-stimuli responsive smart chitosan-based microcapsules for targeted drug delivery and triggered drug release

Xuejun Cui; Xinyu Guan; Shuangling Zhong; Jie Chen; Houjuan Zhu; Zhanfeng Li; Fengzhi Xu; Peng Chen; Hongyan Wang

doi:10.1016/j.ultsonch.2017.03.011

Multi-stimuli responsive smart chitosan-based microcapsules for targeted drug delivery and triggered drug release

Xuejun Cui^*, Xinyu Guan, Shuangling Zhong, Jie Chen, Houjuan Zhu, Zhanfeng Li, Fengzhi Xu, Peng Chen, Hongyan Wang

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

72 Citations (Scopus)

Abstract

In the present study, we designed a novel, multi-stimuli responsive, biocompatible and non-immunogenic smart carrier for targeted delivery and triggered release of hydrophobic drugs. The designed multi-stimuli responsive smart chitosan-based microcapsules (MSRS-CS-MCs) have been fabricated successfully from folic acid (FA) functionalized thiolated chitosan via a facile sonochemical method. Targeting moiety FA and red fluorescent dye (Rhodamine B isothiocyanate, RITC) were immobilized onto the shells of microcapsules. Meanwhile, oleic acid (OA) modified Fe₃O₄ magnetic nanoparticles (OA-Fe₃O₄ MNPs) and a model hydrophobic drug, green fluorescent dye (Coumarin 6, C6), were encapsulated into the microcapsules. As drug carriers, the obtained spherical MSRS-CS-MCs with the average size of 500 nm showed excellent magnetic responsive ability, favorable selectively folate-receptor-mediated targeting functionality to the HeLa cells, and attractive reduction-responsive release ability for hydrophobic drugs. The integration of magnetic and reduction dual-responsiveness, folate-receptor-mediated targeting functionality and fluorescence visualization into the versatile microcapsules make MSRS-CS-MCs promising nanocarriers for future biomedical applications.

Original language	English
Pages (from-to)	145-153
Number of pages	9
Journal	Ultrasonics Sonochemistry
Volume	38
DOIs	https://doi.org/10.1016/j.ultsonch.2017.03.011
Publication status	Published - Sept 1 2017
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2017

ASJC Scopus Subject Areas

Environmental Chemistry
Chemical Engineering (miscellaneous)
Radiology Nuclear Medicine and imaging
Acoustics and Ultrasonics
Organic Chemistry
Inorganic Chemistry

Keywords

Folic acid
Magnetic
Microcapsules
Multi-stimuli responsive
Sonochemical
Targeted drug delivery

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10.1016/j.ultsonch.2017.03.011

Cite this

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abstract = "In the present study, we designed a novel, multi-stimuli responsive, biocompatible and non-immunogenic smart carrier for targeted delivery and triggered release of hydrophobic drugs. The designed multi-stimuli responsive smart chitosan-based microcapsules (MSRS-CS-MCs) have been fabricated successfully from folic acid (FA) functionalized thiolated chitosan via a facile sonochemical method. Targeting moiety FA and red fluorescent dye (Rhodamine B isothiocyanate, RITC) were immobilized onto the shells of microcapsules. Meanwhile, oleic acid (OA) modified Fe3O4 magnetic nanoparticles (OA-Fe3O4 MNPs) and a model hydrophobic drug, green fluorescent dye (Coumarin 6, C6), were encapsulated into the microcapsules. As drug carriers, the obtained spherical MSRS-CS-MCs with the average size of 500 nm showed excellent magnetic responsive ability, favorable selectively folate-receptor-mediated targeting functionality to the HeLa cells, and attractive reduction-responsive release ability for hydrophobic drugs. The integration of magnetic and reduction dual-responsiveness, folate-receptor-mediated targeting functionality and fluorescence visualization into the versatile microcapsules make MSRS-CS-MCs promising nanocarriers for future biomedical applications.",

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AU - Cui, Xuejun

AU - Guan, Xinyu

AU - Zhong, Shuangling

AU - Chen, Jie

AU - Zhu, Houjuan

AU - Li, Zhanfeng

AU - Xu, Fengzhi

AU - Chen, Peng

AU - Wang, Hongyan

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AB - In the present study, we designed a novel, multi-stimuli responsive, biocompatible and non-immunogenic smart carrier for targeted delivery and triggered release of hydrophobic drugs. The designed multi-stimuli responsive smart chitosan-based microcapsules (MSRS-CS-MCs) have been fabricated successfully from folic acid (FA) functionalized thiolated chitosan via a facile sonochemical method. Targeting moiety FA and red fluorescent dye (Rhodamine B isothiocyanate, RITC) were immobilized onto the shells of microcapsules. Meanwhile, oleic acid (OA) modified Fe3O4 magnetic nanoparticles (OA-Fe3O4 MNPs) and a model hydrophobic drug, green fluorescent dye (Coumarin 6, C6), were encapsulated into the microcapsules. As drug carriers, the obtained spherical MSRS-CS-MCs with the average size of 500 nm showed excellent magnetic responsive ability, favorable selectively folate-receptor-mediated targeting functionality to the HeLa cells, and attractive reduction-responsive release ability for hydrophobic drugs. The integration of magnetic and reduction dual-responsiveness, folate-receptor-mediated targeting functionality and fluorescence visualization into the versatile microcapsules make MSRS-CS-MCs promising nanocarriers for future biomedical applications.

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KW - Sonochemical

KW - Targeted drug delivery

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Multi-stimuli responsive smart chitosan-based microcapsules for targeted drug delivery and triggered drug release

Abstract

Bibliographical note

ASJC Scopus Subject Areas

Keywords

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