Multienzyme nanoassemblies: From rational design to biomedical applications

Di Li; Qirong Xiong; Li Liang; Hongwei Duan

doi:10.1039/d1bm01106e

Multienzyme nanoassemblies: From rational design to biomedical applications

Di Li, Qirong Xiong, Li Liang^*, Hongwei Duan^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

9 Citations (Scopus)

Abstract

Multienzyme nanoassemblies (MENAs) that combine the functions of several enzymes into one entity have attracted widespread research interest due to their improved enzymatic performance and great potential for multiple applications. Considerable progress has been made to design and fabricate MENAs in recent years. This review begins with an introduction of the up-to-date strategies in designing MENAs, mainly including substrate channeling, compartmentalization and control of enzyme stoichiometry. The desirable properties that endow MENAs with important applications are also discussed in detail. Then, the recent advances in utilizing MENAs in the biomedical field are reviewed, with a particular focus on biosensing, tumor therapy, antioxidant and drug delivery. Finally, the challenges and perspectives for development of versatile MENAs are summarized.

Original language	English
Pages (from-to)	7323-7342
Number of pages	20
Journal	Biomaterials Science
Volume	9
Issue number	22
DOIs	https://doi.org/10.1039/d1bm01106e
Publication status	Published - Nov 21 2021
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2021 The Royal Society of Chemistry.

ASJC Scopus Subject Areas

Biomedical Engineering
General Materials Science

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10.1039/d1bm01106e

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abstract = "Multienzyme nanoassemblies (MENAs) that combine the functions of several enzymes into one entity have attracted widespread research interest due to their improved enzymatic performance and great potential for multiple applications. Considerable progress has been made to design and fabricate MENAs in recent years. This review begins with an introduction of the up-to-date strategies in designing MENAs, mainly including substrate channeling, compartmentalization and control of enzyme stoichiometry. The desirable properties that endow MENAs with important applications are also discussed in detail. Then, the recent advances in utilizing MENAs in the biomedical field are reviewed, with a particular focus on biosensing, tumor therapy, antioxidant and drug delivery. Finally, the challenges and perspectives for development of versatile MENAs are summarized.",

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AU - Liang, Li

AU - Duan, Hongwei

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Y1 - 2021/11/21

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Multienzyme nanoassemblies: From rational design to biomedical applications

Abstract

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