Multifunctional Glyco-Nanosheets to Eradicate Drug-Resistant Bacteria on Wounds

Zhong Guo, Jing Xi He, Surendra H. Mahadevegowda, Shu Hui Kho, Mary B. Chan-Park, Xue Wei Liu*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

46 Citations (Scopus)

Abstract

Bacterial infection is becoming increasingly lethal with the emergence of antimicrobial resistance, and wounds plagued by such infection are notoriously difficult to heal. Here, the first use of galactose-black phosphorus nanosheets, (Gal-BP NSs) as a delivery platform for synergistic antibiotic (kanamycin, Kana) and photothermal treatments against the Gram-negative microbial strain, Pseudomonas aeruginosa PAO1 (PAO1) is reported. Gal-BP NSs@Kana can actively target PAO1 and release kanamycin into the bacterial cytoplasm upon near-infrared laser irradiation. This strategy kills most of the PAO1 through a simultaneous burst of intracellular kanamycin release and photothermal treatment. Comparable antibacterial activities of Gal-BP NSs@Kana are observed within in vivo mouse models at their wound sites. In addition, this platform accelerates wound healing from PAO1 infection via promotion of neoangiogenesis and collagen production at the wound sites. This work demonstrates the material properties of Gal-BP NS in fighting bacterial infections and in the treatment of wound healing.

Original languageEnglish
Article number2000265
JournalAdvanced healthcare materials
Volume9
Issue number10
DOIs
Publication statusPublished - May 1 2020
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim

ASJC Scopus Subject Areas

  • Biomaterials
  • Biomedical Engineering
  • Pharmaceutical Science

Keywords

  • active targeting
  • bacteria
  • black phosphorus nanosheets
  • carbohydrates
  • wound healing

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