N-Heterocyclic carbene catalyzed aza-benzoin reaction for access to α-aminoketone molecules containing benzothiazole fragments

Wei Li; Jie Lv; Yonggui Robin Chi

doi:10.1016/j.tet.2021.132311

N-Heterocyclic carbene catalyzed aza-benzoin reaction for access to α-aminoketone molecules containing benzothiazole fragments

Wei Li, Jie Lv, Yonggui Robin Chi^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

An N-Heterocyclic carbene (NHC) catalyzed aza-benzoin reaction of benzothiazole-2-carboxaldehydes and N-sulfonylimines is reported for the first time. The target benzothiazole-containing aminoketone products bearing different substituents and substitution patterns can be obtained in good to excellent yields under mild conditions.

Original language	English
Article number	132311
Journal	Tetrahedron
Volume	94
DOIs	https://doi.org/10.1016/j.tet.2021.132311
Publication status	Published - Aug 13 2021
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2021

ASJC Scopus Subject Areas

Biochemistry
Drug Discovery
Organic Chemistry

Keywords

Aza-benzoin reaction
Benzothiazole derivatives
N-Heterocyclic carbene
Organocatalysis

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10.1016/j.tet.2021.132311

Cite this

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title = "N-Heterocyclic carbene catalyzed aza-benzoin reaction for access to α-aminoketone molecules containing benzothiazole fragments",

abstract = "An N-Heterocyclic carbene (NHC) catalyzed aza-benzoin reaction of benzothiazole-2-carboxaldehydes and N-sulfonylimines is reported for the first time. The target benzothiazole-containing aminoketone products bearing different substituents and substitution patterns can be obtained in good to excellent yields under mild conditions.",

keywords = "Aza-benzoin reaction, Benzothiazole derivatives, N-Heterocyclic carbene, Organocatalysis",

author = "Wei Li and Jie Lv and Chi, {Yonggui Robin}",

note = "Publisher Copyright: {\textcopyright} 2021",

year = "2021",

month = aug,

day = "13",

doi = "10.1016/j.tet.2021.132311",

language = "English",

volume = "94",

journal = "Tetrahedron",

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TY - JOUR

T1 - N-Heterocyclic carbene catalyzed aza-benzoin reaction for access to α-aminoketone molecules containing benzothiazole fragments

AU - Li, Wei

AU - Lv, Jie

AU - Chi, Yonggui Robin

PY - 2021/8/13

Y1 - 2021/8/13

N2 - An N-Heterocyclic carbene (NHC) catalyzed aza-benzoin reaction of benzothiazole-2-carboxaldehydes and N-sulfonylimines is reported for the first time. The target benzothiazole-containing aminoketone products bearing different substituents and substitution patterns can be obtained in good to excellent yields under mild conditions.

AB - An N-Heterocyclic carbene (NHC) catalyzed aza-benzoin reaction of benzothiazole-2-carboxaldehydes and N-sulfonylimines is reported for the first time. The target benzothiazole-containing aminoketone products bearing different substituents and substitution patterns can be obtained in good to excellent yields under mild conditions.

KW - Aza-benzoin reaction

KW - Benzothiazole derivatives

KW - N-Heterocyclic carbene

KW - Organocatalysis

UR - http://www.scopus.com/inward/record.url?scp=85110291011&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85110291011&partnerID=8YFLogxK

U2 - 10.1016/j.tet.2021.132311

DO - 10.1016/j.tet.2021.132311

M3 - Article

AN - SCOPUS:85110291011

SN - 0040-4020

VL - 94

JO - Tetrahedron

JF - Tetrahedron

M1 - 132311

ER -

N-Heterocyclic carbene catalyzed aza-benzoin reaction for access to α-aminoketone molecules containing benzothiazole fragments

Abstract

Bibliographical note

ASJC Scopus Subject Areas

Keywords

Access to Document

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