TY - JOUR
T1 - N-Heterocyclic carbene catalyzed C-acylation reaction for access to linear aminoenones
AU - Lv, Jie
AU - Nong, Yingling
AU - Chen, Kai
AU - Wang, Qingyun
AU - Jin, Jiamiao
AU - Li, Tingting
AU - Jin, Zhichao
AU - Chi, Yonggui Robin
N1 - Publisher Copyright:
© 2022
PY - 2023/1
Y1 - 2023/1
N2 - An N-heterocyclic carbene (NHC)-catalyzed carbonyl nucleophilic substitution reaction between 1-cyclopropylcarbaldehydes and N-sulfonyl imines is developed for access to linear β-aminoenone products. The β-aminoenones containing cyclopropyl fragments can be afforded in moderate to excellent yields under mild conditions. The reaction features excellent trans-diastereoselectivities and the desired aminoenone products are all afforded as Z-isomers.
AB - An N-heterocyclic carbene (NHC)-catalyzed carbonyl nucleophilic substitution reaction between 1-cyclopropylcarbaldehydes and N-sulfonyl imines is developed for access to linear β-aminoenone products. The β-aminoenones containing cyclopropyl fragments can be afforded in moderate to excellent yields under mild conditions. The reaction features excellent trans-diastereoselectivities and the desired aminoenone products are all afforded as Z-isomers.
KW - Animoenone synthesis
KW - C-Acylation reaction
KW - N-Heterocyclic carbene
KW - Organocatalysis
UR - http://www.scopus.com/inward/record.url?scp=85140334511&partnerID=8YFLogxK
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U2 - 10.1016/j.cclet.2022.05.084
DO - 10.1016/j.cclet.2022.05.084
M3 - Article
AN - SCOPUS:85140334511
SN - 1001-8417
VL - 34
JO - Chinese Chemical Letters
JF - Chinese Chemical Letters
IS - 1
M1 - 107570
ER -