Abstract
N-Heterocyclic carbene catalyzed radical reactions are challenging and underdeveloped. In a recent study, Ohmiya, Nagao and co-workers found that aldehyde carbonyl carbon centers can be coupled with alkyl radicals under NHC catalysis. An elegant aspect of this study is the use of a redox-active carboxylic ester that behaves as an single-electron oxidant to convert the Breslow intermediate into a radical adduct and concurrently release an alkyl radical intermediate as a reaction partner.
| Original language | English |
|---|---|
| Pages (from-to) | 8628-8630 |
| Number of pages | 3 |
| Journal | Angewandte Chemie - International Edition |
| Volume | 58 |
| Issue number | 26 |
| DOIs | |
| Publication status | Published - Jun 24 2019 |
| Externally published | Yes |
Bibliographical note
Publisher Copyright:© 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
ASJC Scopus Subject Areas
- Catalysis
- General Chemistry
Keywords
- ketones
- N-heterocyclic carbenes
- radical intermediates
- redox-active esters
- single-electron-transfer reactions