Nanocapsules Produced by Nanoprecipitation of Designed Suckerin-Silk Fusion Proteins

Ricardo Ramos, Kenrick Koh, Bartosz Gabryelczyk, Luxiao Chai, Deepankumar Kanagavel, Xibo Yan, François Ganachaud, Ali Miserez*, Julien Bernard*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)

Abstract

Herein, we report on the precise design of a modular fusion protein amenable to the construction of nanocapsules by nanoprecipitation. The central squid suckerin-derived peptide block provides structural stability, whereas both termini from spider silk fibroins make the protein highly soluble at physiological pH, a critical requirement for the nanoprecipitation process. With this design, nanocapsules consisting of fusion protein shells and oily cores with sizes in the range of 190-250 nm are built in a straightforward manner.

Original languageEnglish
Pages (from-to)628-634
Number of pages7
JournalACS Macro Letters
Volume10
Issue number5
DOIs
Publication statusPublished - May 18 2021
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2021 American Chemical Society. All rights reserved.

ASJC Scopus Subject Areas

  • Organic Chemistry
  • Polymers and Plastics
  • Inorganic Chemistry
  • Materials Chemistry

Fingerprint

Dive into the research topics of 'Nanocapsules Produced by Nanoprecipitation of Designed Suckerin-Silk Fusion Proteins'. Together they form a unique fingerprint.

Cite this