Nanochannel-Confined Graphene Quantum Dots for Ultrasensitive Electrochemical Analysis of Complex Samples

Lili Lu; Lin Zhou; Jie Chen; Fei Yan; Jiyang Liu; Xiaoping Dong; Fengna Xi; Peng Chen

doi:10.1021/acsnano.8b07564

Nanochannel-Confined Graphene Quantum Dots for Ultrasensitive Electrochemical Analysis of Complex Samples

Lili Lu, Lin Zhou, Jie Chen, Fei Yan, Jiyang Liu^*, Xiaoping Dong, Fengna Xi, Peng Chen

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

152 Citations (Scopus)

Abstract

Herein, we present an electrochemical sensing platform based on nanochannel-confined graphene quantum dots (GQDs) that is able to detect a spectrum of small analytes in complex samples with high sensitivity. Vertically ordered mesoporous silica-nanochannel film (VMSF) is decorated on the supporting electrode, conferring the electrode with excellent antifouling and anti-interference properties through steric exclusion and electrostatic repulsion. The synthesized GQDs with different functionalities are confined in the nanochannels of VMSF through electrophoresis, serving as the recognition element and signal amplifier. Without the usual need of tedious pretreatment, ultrasensitive and fast detection of Hg ²⁺ , Cu ²⁺ , and Cd ²⁺ (with limits of detection (LOD) of 9.8 pM, 8.3 pM, and 4.3 nM, respectively) and dopamine (LOD of 120 nM) in complex food (Hg ²⁺ -contaminated seafood), environmental (soil-leaching solution), and biological (serum) samples are realized as proof-of-concept demonstrations.

Original language	English
Pages (from-to)	12673-12681
Number of pages	9
Journal	ACS Nano
Volume	12
Issue number	12
DOIs	https://doi.org/10.1021/acsnano.8b07564
Publication status	Published - Dec 26 2018
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2018 American Chemical Society.

ASJC Scopus Subject Areas

General Materials Science
General Engineering
General Physics and Astronomy

Keywords

biomarker detection
electrochemical detection
graphene quantum dots
heavy metal ion detection
vertically ordered mesoporous silica-nanochannel

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10.1021/acsnano.8b07564

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abstract = " Herein, we present an electrochemical sensing platform based on nanochannel-confined graphene quantum dots (GQDs) that is able to detect a spectrum of small analytes in complex samples with high sensitivity. Vertically ordered mesoporous silica-nanochannel film (VMSF) is decorated on the supporting electrode, conferring the electrode with excellent antifouling and anti-interference properties through steric exclusion and electrostatic repulsion. The synthesized GQDs with different functionalities are confined in the nanochannels of VMSF through electrophoresis, serving as the recognition element and signal amplifier. Without the usual need of tedious pretreatment, ultrasensitive and fast detection of Hg 2+ , Cu 2+ , and Cd 2+ (with limits of detection (LOD) of 9.8 pM, 8.3 pM, and 4.3 nM, respectively) and dopamine (LOD of 120 nM) in complex food (Hg 2+ -contaminated seafood), environmental (soil-leaching solution), and biological (serum) samples are realized as proof-of-concept demonstrations.",

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author = "Lili Lu and Lin Zhou and Jie Chen and Fei Yan and Jiyang Liu and Xiaoping Dong and Fengna Xi and Peng Chen",

note = "Publisher Copyright: {\textcopyright} 2018 American Chemical Society.",

year = "2018",

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day = "26",

doi = "10.1021/acsnano.8b07564",

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T1 - Nanochannel-Confined Graphene Quantum Dots for Ultrasensitive Electrochemical Analysis of Complex Samples

AU - Lu, Lili

AU - Zhou, Lin

AU - Chen, Jie

AU - Yan, Fei

AU - Liu, Jiyang

AU - Dong, Xiaoping

AU - Xi, Fengna

AU - Chen, Peng

PY - 2018/12/26

Y1 - 2018/12/26

N2 - Herein, we present an electrochemical sensing platform based on nanochannel-confined graphene quantum dots (GQDs) that is able to detect a spectrum of small analytes in complex samples with high sensitivity. Vertically ordered mesoporous silica-nanochannel film (VMSF) is decorated on the supporting electrode, conferring the electrode with excellent antifouling and anti-interference properties through steric exclusion and electrostatic repulsion. The synthesized GQDs with different functionalities are confined in the nanochannels of VMSF through electrophoresis, serving as the recognition element and signal amplifier. Without the usual need of tedious pretreatment, ultrasensitive and fast detection of Hg 2+ , Cu 2+ , and Cd 2+ (with limits of detection (LOD) of 9.8 pM, 8.3 pM, and 4.3 nM, respectively) and dopamine (LOD of 120 nM) in complex food (Hg 2+ -contaminated seafood), environmental (soil-leaching solution), and biological (serum) samples are realized as proof-of-concept demonstrations.

AB - Herein, we present an electrochemical sensing platform based on nanochannel-confined graphene quantum dots (GQDs) that is able to detect a spectrum of small analytes in complex samples with high sensitivity. Vertically ordered mesoporous silica-nanochannel film (VMSF) is decorated on the supporting electrode, conferring the electrode with excellent antifouling and anti-interference properties through steric exclusion and electrostatic repulsion. The synthesized GQDs with different functionalities are confined in the nanochannels of VMSF through electrophoresis, serving as the recognition element and signal amplifier. Without the usual need of tedious pretreatment, ultrasensitive and fast detection of Hg 2+ , Cu 2+ , and Cd 2+ (with limits of detection (LOD) of 9.8 pM, 8.3 pM, and 4.3 nM, respectively) and dopamine (LOD of 120 nM) in complex food (Hg 2+ -contaminated seafood), environmental (soil-leaching solution), and biological (serum) samples are realized as proof-of-concept demonstrations.

KW - biomarker detection

KW - electrochemical detection

KW - graphene quantum dots

KW - heavy metal ion detection

KW - vertically ordered mesoporous silica-nanochannel

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Nanochannel-Confined Graphene Quantum Dots for Ultrasensitive Electrochemical Analysis of Complex Samples

Abstract

Bibliographical note

ASJC Scopus Subject Areas

Keywords

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