TY - GEN
T1 - Nanopore devices for single molecule sensing
AU - Wang, Qiao
AU - Chen, Peng
PY - 2006
Y1 - 2006
N2 - Protein nanopores spanning a lipid bilayer membrane have been demonstrated as single molecule sensors that are highly sensitive to minute differences in the chemical and physical properties of the passing molecules. Nevertheless, their fixed aperture size, delicate physico-chemical, mechanical and electrical properties greatly limit the range of analytes and the repertoire of experimental possibilities. To overcome these limitations, nanoscale apertures on solid-state materials have been fabricated using state-of-the-art nanotechnologies, and have been used to probe the molecular characteristics of single nucleic acid chains.
AB - Protein nanopores spanning a lipid bilayer membrane have been demonstrated as single molecule sensors that are highly sensitive to minute differences in the chemical and physical properties of the passing molecules. Nevertheless, their fixed aperture size, delicate physico-chemical, mechanical and electrical properties greatly limit the range of analytes and the repertoire of experimental possibilities. To overcome these limitations, nanoscale apertures on solid-state materials have been fabricated using state-of-the-art nanotechnologies, and have been used to probe the molecular characteristics of single nucleic acid chains.
UR - http://www.scopus.com/inward/record.url?scp=33750841747&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33750841747&partnerID=8YFLogxK
U2 - 10.1109/NANOEL.2006.1609714
DO - 10.1109/NANOEL.2006.1609714
M3 - Conference contribution
AN - SCOPUS:33750841747
SN - 0780393589
SN - 9780780393585
T3 - NanoSingapore 2006: IEEE Conference on Emerging Technologies - Nanoelectronics - Proceedings
SP - 211
EP - 215
BT - NanoSingapore 2006
T2 - 2006 IEEE Conference on Emerging Technologies - Nanoelectronics
Y2 - 10 January 2006 through 13 January 2006
ER -