Neodymium-Sensitized Nanoconstructs for Near-Infrared Enabled Photomedicine

Zhongzheng Yu; Wen Kiat Chan; Timothy Thatt Yang Tan

doi:10.1002/smll.201905265

Neodymium-Sensitized Nanoconstructs for Near-Infrared Enabled Photomedicine

Zhongzheng Yu, Wen Kiat Chan, Timothy Thatt Yang Tan^*

^*Corresponding author for this work

Nanyang Technological University

Research output: Contribution to journal › Review article › peer-review

38 Citations (Scopus)

Abstract

Neodymium (Nd³⁺)-sensitized nanoconstructs have gained increasing attention in recent decades due to their unique properties, especially optical properties. The design of various Nd³⁺-sensitized nanosystems is expected to contribute to medical and health applications, due to their advantageous properties such as high penetration depth, excellent photostability, non-photobleaching, low cytotoxicity, etc. However, the low conversion efficiency and potential long-term toxicity of Nd³⁺-sensitized nanoconstructs are huge obstacles to their clinical translations. This review article summarizes three energy transfer pathways of all kinds of Nd³⁺-sensitized nanoconstructs focusing on the properties of Nd³⁺ ions and discusses their recent potential applications as near-infrared (NIR) enabled photomedicine. This review article will contribute to the design and fabrication of novel Nd³⁺-sensitized nanoconstructs for NIR-enabled photomedicine, aiming for potentially safer and more efficient designs to get closer to clinical usage.

Original language	English
Article number	1905265
Journal	Small
Volume	16
Issue number	1
DOIs	https://doi.org/10.1002/smll.201905265
Publication status	Published - Jan 1 2020
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim

ASJC Scopus Subject Areas

Biotechnology
General Chemistry
Biomaterials
General Materials Science
Engineering (miscellaneous)

Keywords

energy transfer pathways
nanoconstructs
Nd -sensitization
photomedicine

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10.1002/smll.201905265

Cite this

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abstract = "Neodymium (Nd3+)-sensitized nanoconstructs have gained increasing attention in recent decades due to their unique properties, especially optical properties. The design of various Nd3+-sensitized nanosystems is expected to contribute to medical and health applications, due to their advantageous properties such as high penetration depth, excellent photostability, non-photobleaching, low cytotoxicity, etc. However, the low conversion efficiency and potential long-term toxicity of Nd3+-sensitized nanoconstructs are huge obstacles to their clinical translations. This review article summarizes three energy transfer pathways of all kinds of Nd3+-sensitized nanoconstructs focusing on the properties of Nd3+ ions and discusses their recent potential applications as near-infrared (NIR) enabled photomedicine. This review article will contribute to the design and fabrication of novel Nd3+-sensitized nanoconstructs for NIR-enabled photomedicine, aiming for potentially safer and more efficient designs to get closer to clinical usage.",

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N2 - Neodymium (Nd3+)-sensitized nanoconstructs have gained increasing attention in recent decades due to their unique properties, especially optical properties. The design of various Nd3+-sensitized nanosystems is expected to contribute to medical and health applications, due to their advantageous properties such as high penetration depth, excellent photostability, non-photobleaching, low cytotoxicity, etc. However, the low conversion efficiency and potential long-term toxicity of Nd3+-sensitized nanoconstructs are huge obstacles to their clinical translations. This review article summarizes three energy transfer pathways of all kinds of Nd3+-sensitized nanoconstructs focusing on the properties of Nd3+ ions and discusses their recent potential applications as near-infrared (NIR) enabled photomedicine. This review article will contribute to the design and fabrication of novel Nd3+-sensitized nanoconstructs for NIR-enabled photomedicine, aiming for potentially safer and more efficient designs to get closer to clinical usage.

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Neodymium-Sensitized Nanoconstructs for Near-Infrared Enabled Photomedicine

Abstract

Bibliographical note

ASJC Scopus Subject Areas

Keywords

Access to Document

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