TY - JOUR
T1 - Neutralizing antibodies against Plasmodium falciparum associated with successful cure after drug therapy
AU - Goh, Yun Shan
AU - Peng, Kaitian
AU - Chia, Wan Ni
AU - Siau, Anthony
AU - Chotivanich, Kesinee
AU - Gruner, Anne Charlotte
AU - Preiser, Peter
AU - Mayxay, Mayfong
AU - Pukrittayakamee, Sasithon
AU - Sriprawat, Kanlaya
AU - Nosten, Francois
AU - White, Nicholas J.
AU - Renia, Laurent
N1 - Publisher Copyright:
© 2016 Goh et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
PY - 2016/7/1
Y1 - 2016/7/1
N2 - An effective antibody response can assist drug treatment to contribute to better parasite clearance in malaria patients. To examine this, sera were obtained from two groups of adult patients with acute falciparum malaria, prior to drug treatment: patients who (1) have subsequent recrudescent infection, or (2) were cured by Day 28 following treatment. Using a Plasmodium falciparum antigen library, we examined the antibody specificities in these sera. While the antibody repertoire of both sera groups was extremely broad and varied, there was a differential antibody profile between the two groups of sera. The proportion of cured patients with antibodies against EXP1, MSP3, GLURP, RAMA, SEA and EBA181 was higher than the proportion of patients with recrudescent infection. The presence of these antibodies was associated with higher odds of treatment cure. Sera containing all six antibodies impaired the invasion of P. falciparum clinical isolates into erythrocytes. These results suggest that antibodies specific against EXP1, MSP3, GLURP, RAMA, SEA and EBA181 in P. falciparum infections could assist anti-malarial drug treatment and contribute to the resolution of the malarial infection.
AB - An effective antibody response can assist drug treatment to contribute to better parasite clearance in malaria patients. To examine this, sera were obtained from two groups of adult patients with acute falciparum malaria, prior to drug treatment: patients who (1) have subsequent recrudescent infection, or (2) were cured by Day 28 following treatment. Using a Plasmodium falciparum antigen library, we examined the antibody specificities in these sera. While the antibody repertoire of both sera groups was extremely broad and varied, there was a differential antibody profile between the two groups of sera. The proportion of cured patients with antibodies against EXP1, MSP3, GLURP, RAMA, SEA and EBA181 was higher than the proportion of patients with recrudescent infection. The presence of these antibodies was associated with higher odds of treatment cure. Sera containing all six antibodies impaired the invasion of P. falciparum clinical isolates into erythrocytes. These results suggest that antibodies specific against EXP1, MSP3, GLURP, RAMA, SEA and EBA181 in P. falciparum infections could assist anti-malarial drug treatment and contribute to the resolution of the malarial infection.
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U2 - 10.1371/journal.pone.0159347
DO - 10.1371/journal.pone.0159347
M3 - Article
C2 - 27427762
AN - SCOPUS:84979207880
SN - 1932-6203
VL - 11
JO - PLoS One
JF - PLoS One
IS - 7
M1 - e0159347
ER -
