Next-generation materials for nucleic acid delivery

Roy van der Meel; Paul A. Wender; Olivia M. Merkel; Irene Lostalé-Seijo; Javier Montenegro; Ali Miserez; Quentin Laurent; Hanadi Sleiman; Paola Luciani

doi:10.1038/s41578-025-00814-1

Next-generation materials for nucleic acid delivery

Roy van der Meel^*, Paul A. Wender^*, Olivia M. Merkel^*, Irene Lostalé-Seijo^*, Javier Montenegro^*, Ali Miserez^*, Quentin Laurent^*, Hanadi Sleiman^*, Paola Luciani^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

Efficient and targeted delivery of nucleic acids is critical for realizing the full therapeutic potential of gene editing, vaccines and RNA-based drugs, and emerging delivery platforms offer innovative solutions through their diverse architectures, tunable properties and distinct biological interactions. In this Viewpoint, researchers working across different delivery platforms — including lipid nanoparticles, synthetic polymers, peptide amphiphiles, coacervate microdroplets, DNA nanostructures and extracellular vesicles — discuss the most promising directions and the main challenges in shaping the future of nucleic acid delivery.

Original language	English
Journal	Nature Reviews Materials
DOIs	https://doi.org/10.1038/s41578-025-00814-1
Publication status	Accepted/In press - 2025
Externally published	Yes

Bibliographical note

Publisher Copyright:
© Springer Nature Limited 2025.

ASJC Scopus Subject Areas

Electronic, Optical and Magnetic Materials
Biomaterials
Energy (miscellaneous)
Surfaces, Coatings and Films
Materials Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/s41578-025-00814-1

Cite this

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title = "Next-generation materials for nucleic acid delivery",

abstract = "Efficient and targeted delivery of nucleic acids is critical for realizing the full therapeutic potential of gene editing, vaccines and RNA-based drugs, and emerging delivery platforms offer innovative solutions through their diverse architectures, tunable properties and distinct biological interactions. In this Viewpoint, researchers working across different delivery platforms — including lipid nanoparticles, synthetic polymers, peptide amphiphiles, coacervate microdroplets, DNA nanostructures and extracellular vesicles — discuss the most promising directions and the main challenges in shaping the future of nucleic acid delivery.",

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year = "2025",

doi = "10.1038/s41578-025-00814-1",

language = "English",

journal = "Nature Reviews Materials",

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T1 - Next-generation materials for nucleic acid delivery

AU - van der Meel, Roy

AU - Wender, Paul A.

AU - Merkel, Olivia M.

AU - Lostalé-Seijo, Irene

AU - Montenegro, Javier

AU - Miserez, Ali

AU - Laurent, Quentin

AU - Sleiman, Hanadi

AU - Luciani, Paola

PY - 2025

Y1 - 2025

N2 - Efficient and targeted delivery of nucleic acids is critical for realizing the full therapeutic potential of gene editing, vaccines and RNA-based drugs, and emerging delivery platforms offer innovative solutions through their diverse architectures, tunable properties and distinct biological interactions. In this Viewpoint, researchers working across different delivery platforms — including lipid nanoparticles, synthetic polymers, peptide amphiphiles, coacervate microdroplets, DNA nanostructures and extracellular vesicles — discuss the most promising directions and the main challenges in shaping the future of nucleic acid delivery.

AB - Efficient and targeted delivery of nucleic acids is critical for realizing the full therapeutic potential of gene editing, vaccines and RNA-based drugs, and emerging delivery platforms offer innovative solutions through their diverse architectures, tunable properties and distinct biological interactions. In this Viewpoint, researchers working across different delivery platforms — including lipid nanoparticles, synthetic polymers, peptide amphiphiles, coacervate microdroplets, DNA nanostructures and extracellular vesicles — discuss the most promising directions and the main challenges in shaping the future of nucleic acid delivery.

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M3 - Article

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SN - 2058-8437

JO - Nature Reviews Materials

JF - Nature Reviews Materials

ER -

Next-generation materials for nucleic acid delivery

Abstract

Bibliographical note

ASJC Scopus Subject Areas

UN SDGs

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