NHC-Catalyzed Reaction of Carboxylic Acids Using Allene Ketones as Substrates and Activating Reagents

Chengli Mou; Ya Lv; Jiamiao Jin; Huifang Chai; Tingting Li; Yonggui Robin Chi; Zhichao Jin

doi:10.1021/acs.orglett.3c03623

NHC-Catalyzed Reaction of Carboxylic Acids Using Allene Ketones as Substrates and Activating Reagents

Chengli Mou, Ya Lv, Jiamiao Jin, Huifang Chai, Tingting Li, Yonggui Robin Chi, Zhichao Jin^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

We present a new reaction between carboxylic acids and allene ketones mediated by N-heterocyclic carbene (NHC) catalysts, which exhibit, in principle, nearly perfect atom economy. In this new approach, allene ketones act as both an activating reagent and a reactant. All atoms in the substrates end up in the product without the need for coupling reagents. The present study aims to encourage further explorations of NHC catalytic reactions with alternative activation strategies and better atom economy.

Original language	English
Pages (from-to)	8706-8710
Number of pages	5
Journal	Organic Letters
Volume	25
Issue number	48
DOIs	https://doi.org/10.1021/acs.orglett.3c03623
Publication status	Published - Dec 8 2023
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2023 American Chemical Society.

ASJC Scopus Subject Areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/acs.orglett.3c03623

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abstract = "We present a new reaction between carboxylic acids and allene ketones mediated by N-heterocyclic carbene (NHC) catalysts, which exhibit, in principle, nearly perfect atom economy. In this new approach, allene ketones act as both an activating reagent and a reactant. All atoms in the substrates end up in the product without the need for coupling reagents. The present study aims to encourage further explorations of NHC catalytic reactions with alternative activation strategies and better atom economy.",

author = "Chengli Mou and Ya Lv and Jiamiao Jin and Huifang Chai and Tingting Li and Chi, {Yonggui Robin} and Zhichao Jin",

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T1 - NHC-Catalyzed Reaction of Carboxylic Acids Using Allene Ketones as Substrates and Activating Reagents

AU - Mou, Chengli

AU - Lv, Ya

AU - Jin, Jiamiao

AU - Chai, Huifang

AU - Li, Tingting

AU - Chi, Yonggui Robin

AU - Jin, Zhichao

PY - 2023/12/8

Y1 - 2023/12/8

N2 - We present a new reaction between carboxylic acids and allene ketones mediated by N-heterocyclic carbene (NHC) catalysts, which exhibit, in principle, nearly perfect atom economy. In this new approach, allene ketones act as both an activating reagent and a reactant. All atoms in the substrates end up in the product without the need for coupling reagents. The present study aims to encourage further explorations of NHC catalytic reactions with alternative activation strategies and better atom economy.

AB - We present a new reaction between carboxylic acids and allene ketones mediated by N-heterocyclic carbene (NHC) catalysts, which exhibit, in principle, nearly perfect atom economy. In this new approach, allene ketones act as both an activating reagent and a reactant. All atoms in the substrates end up in the product without the need for coupling reagents. The present study aims to encourage further explorations of NHC catalytic reactions with alternative activation strategies and better atom economy.

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JO - Organic Letters

JF - Organic Letters

IS - 48

ER -

NHC-Catalyzed Reaction of Carboxylic Acids Using Allene Ketones as Substrates and Activating Reagents

Abstract

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ASJC Scopus Subject Areas

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