TY - JOUR
T1 - Nickel-Catalyzed Enantioselective Reductive Arylation and Heteroarylation of Aldimines via an Elementary 1,4-Addition
AU - Zhang, Luoqiang
AU - Wang, Xiuhua
AU - Pu, Maoping
AU - Chen, Caiyou
AU - Yang, Peng
AU - Wu, Yun Dong
AU - Chi, Yonggui Robin
AU - Zhou, Jianrong Steve
N1 - Publisher Copyright:
© 2023 American Chemical Society.
PY - 2023
Y1 - 2023
N2 - Nickel catalysts of chiral pyrox ligands promoted enantioselective reductive arylation and heteroarylation of aldimines, using directly (hetero)aryl halides and sulfonates. The catalytic arylation can also be conducted with crude aldimines generated from condensation of aldehydes and azaaryl amines. Mechanistically, density functional theory (DFT) calculations and experiments pointed to an elementary step of 1,4-addition of aryl nickel(I) complexes to N-azaaryl aldimines.
AB - Nickel catalysts of chiral pyrox ligands promoted enantioselective reductive arylation and heteroarylation of aldimines, using directly (hetero)aryl halides and sulfonates. The catalytic arylation can also be conducted with crude aldimines generated from condensation of aldehydes and azaaryl amines. Mechanistically, density functional theory (DFT) calculations and experiments pointed to an elementary step of 1,4-addition of aryl nickel(I) complexes to N-azaaryl aldimines.
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U2 - 10.1021/jacs.3c00548
DO - 10.1021/jacs.3c00548
M3 - Article
C2 - 37023358
AN - SCOPUS:85152138176
SN - 0002-7863
JO - Journal of the American Chemical Society
JF - Journal of the American Chemical Society
ER -