Nonconventional difluoroalkylation of C(sp2)-H bonds through hydroarylation

Chuan Zhu; Shengjin Song; Lu Zhou; Ding Xing Wang; Chao Feng; Teck Peng Loh

doi:10.1039/c7cc04842d

Nonconventional difluoroalkylation of C(sp²)-H bonds through hydroarylation

Chuan Zhu, Shengjin Song, Lu Zhou, Ding Xing Wang, Chao Feng^*, Teck Peng Loh

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

35 Citations (Scopus)

Abstract

An unprecedented Rh-catalyzed C2-difluoroalkylation of indole derivatives with 2,2-difluorovinyl arenesulfonates has been reported. This reaction provides a rare instance of catalytic difluoroalkylation through hydroarylation of gem-difluoroalkenes. The sulfonate group works as a chelating ligand, thus stabilizing the rhodacycle intermediate, leading to the uncommon transformation.

Original language	English
Pages (from-to)	9482-9485
Number of pages	4
Journal	Chemical Communications
Volume	53
Issue number	68
DOIs	https://doi.org/10.1039/c7cc04842d
Publication status	Published - 2017
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2017 The Royal Society of Chemistry.

ASJC Scopus Subject Areas

Electronic, Optical and Magnetic Materials
Catalysis
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

Access to Document

10.1039/c7cc04842d

Cite this

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abstract = "An unprecedented Rh-catalyzed C2-difluoroalkylation of indole derivatives with 2,2-difluorovinyl arenesulfonates has been reported. This reaction provides a rare instance of catalytic difluoroalkylation through hydroarylation of gem-difluoroalkenes. The sulfonate group works as a chelating ligand, thus stabilizing the rhodacycle intermediate, leading to the uncommon transformation.",

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AU - Loh, Teck Peng

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