Nuclear hormone receptors and mouse skin homeostasis: Implication of PPARβ

Liliane Michalik; Béatrice Desvergne; Sharmila Basu-Modak; Nguan Soon Tan; Walter Wahli

doi:10.1159/000053269

Nuclear hormone receptors and mouse skin homeostasis: Implication of PPARβ

Liliane Michalik, Béatrice Desvergne, Sharmila Basu-Modak, Nguan Soon Tan, Walter Wahli^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

PPARβ is expressed in the mouse epidermis during fetal development, and progressively disappears from the interfollicular epidermis after birth. Interestingly, its expression is strongly reactivated in the adult epidermis in conditions where keratinocyte proliferation is induced and during wound healing. Data obtained on PPARβ heterozygous mice reveal that PPARβ is implicated in the control of keratinocyte proliferation and is necessary for rapid healing of a skin wound.

Original language	English
Pages (from-to)	263-268
Number of pages	6
Journal	Hormone Research
Volume	54
Issue number	5-6
DOIs	https://doi.org/10.1159/000053269
Publication status	Published - 2000
Externally published	Yes

ASJC Scopus Subject Areas

Endocrinology, Diabetes and Metabolism
Endocrinology

Keywords

Keratinocyte proliferation
Mouse epidermis
PPAR gene expression
Skin wound healing

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1159/000053269

Cite this

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title = "Nuclear hormone receptors and mouse skin homeostasis: Implication of PPARβ",

abstract = "PPARβ is expressed in the mouse epidermis during fetal development, and progressively disappears from the interfollicular epidermis after birth. Interestingly, its expression is strongly reactivated in the adult epidermis in conditions where keratinocyte proliferation is induced and during wound healing. Data obtained on PPARβ heterozygous mice reveal that PPARβ is implicated in the control of keratinocyte proliferation and is necessary for rapid healing of a skin wound.",

keywords = "Keratinocyte proliferation, Mouse epidermis, PPAR gene expression, Skin wound healing",

author = "Liliane Michalik and B{\'e}atrice Desvergne and Sharmila Basu-Modak and \{Soon Tan\}, Nguan and Walter Wahli",

year = "2000",

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T1 - Nuclear hormone receptors and mouse skin homeostasis

T2 - Implication of PPARβ

AU - Michalik, Liliane

AU - Desvergne, Béatrice

AU - Basu-Modak, Sharmila

AU - Soon Tan, Nguan

AU - Wahli, Walter

PY - 2000

Y1 - 2000

N2 - PPARβ is expressed in the mouse epidermis during fetal development, and progressively disappears from the interfollicular epidermis after birth. Interestingly, its expression is strongly reactivated in the adult epidermis in conditions where keratinocyte proliferation is induced and during wound healing. Data obtained on PPARβ heterozygous mice reveal that PPARβ is implicated in the control of keratinocyte proliferation and is necessary for rapid healing of a skin wound.

AB - PPARβ is expressed in the mouse epidermis during fetal development, and progressively disappears from the interfollicular epidermis after birth. Interestingly, its expression is strongly reactivated in the adult epidermis in conditions where keratinocyte proliferation is induced and during wound healing. Data obtained on PPARβ heterozygous mice reveal that PPARβ is implicated in the control of keratinocyte proliferation and is necessary for rapid healing of a skin wound.

KW - Keratinocyte proliferation

KW - Mouse epidermis

KW - PPAR gene expression

KW - Skin wound healing

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IS - 5-6

ER -

Nuclear hormone receptors and mouse skin homeostasis: Implication of PPARβ

Abstract

ASJC Scopus Subject Areas

Keywords

UN SDGs

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