TY - JOUR
T1 - Nucleophilic transition metal based cyclization of allenes
AU - Bates, Roderick W.
AU - Satcharoen, Vachiraporn
PY - 2002/3/6
Y1 - 2002/3/6
N2 - Allenes bearing a pro-nucleophile can be cyclized on treatment with a wide variety of transition metal catalysts and reagents: palladium, cobalt, ruthenium, silver, rhodium, lanthanides, gold. The nucleophilic groups can be nitrogen, oxygen or carbon based and can form rings of various sizes, often with good control of stereochemistry. A variety of mechanisms can be proposed for these reactions and the metal complex can be used to introduce a variety of functional groups during cyclization. Several heterocyclic natural products have been prepared using a selection of these reactions.
AB - Allenes bearing a pro-nucleophile can be cyclized on treatment with a wide variety of transition metal catalysts and reagents: palladium, cobalt, ruthenium, silver, rhodium, lanthanides, gold. The nucleophilic groups can be nitrogen, oxygen or carbon based and can form rings of various sizes, often with good control of stereochemistry. A variety of mechanisms can be proposed for these reactions and the metal complex can be used to introduce a variety of functional groups during cyclization. Several heterocyclic natural products have been prepared using a selection of these reactions.
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U2 - 10.1039/b103904k
DO - 10.1039/b103904k
M3 - Article
C2 - 12108979
AN - SCOPUS:0036126987
SN - 0306-0012
VL - 31
SP - 12
EP - 21
JO - Chemical Society Reviews
JF - Chemical Society Reviews
IS - 1
ER -